Investigating the effect of colchicine on left ventricular function based on conventional and strain echocardiography

Phase 3

Recruiting

• Conditions: Acute anterior STEMI.; ST elevation (STEMI) myocardial infarction of anterior wall; I21.0

• Registration Number: IRCT20231223060504N1
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 January 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

All patients with acute anterior STEMI will be included in the study.

Exclusion Criteria

stroke in the last 3 months
Type 2 Index MI
CABG in the last 3 years or decision to undergo surgery
History of non-skin malignancies in the last 3 years
Inflammatory bowel disease (IBD)
Chronic diarrhea
Neuromuscular diseases with a CK level greater than 3 times the maximum normal (except for diseases that have led to muscle infarction)
Chronic hematological diseases
Current treatment with corticosteroids or other anti-inflammatory drugs
Known sensitivity to colchicine or current chronic treatment with Colchicine
Severe kidney failure (Cr>2 upper limit of the normal range)
Severe liver failure
History of alcohol or drug abuse

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
eft ventricle function. Timepoint: The effect of colchicine on left ventricular function at the beginning of the study (before the start of the intervention) and 4 to 6 weeks after administration. Method of measurement: Echocardiography machine.