Inhibition of Caspase-1 Reduces Pyroptotic Neuroinflammation and Tissue Factor-Induced Cerebrospinal Fluid Circulation Impairment After Subarachnoid Hemorrhage
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- modified Rankin Scale
研究概览
简要总结
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.
详细描述
Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH).
1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors.
2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •SAH patients with modified Fisher Scale 3-4.
排除标准
- •Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study
结局指标
主要结局
modified Rankin Scale
时间窗: evaluated 1day after discharge
modified Rankin Scale (mRS) at discharge. mRS ranging from 0-5, higher represents worse
Length of hospital stay
时间窗: evaluated 1day after discharge
Length of hospital stay
Glasgow Outcome Scale
时间窗: evaluated 1day after discharge
Glasgow Outcome Scale (GOS) at discharge, GOS ranging from 0-5, higher represents better
次要结局
未报告次要终点