Investigate the Relationship Between Inflammatory and Coagulation in SAH CSF

Completed

• Conditions: Subarachnoid Hemorrhage, Aneurysmal

• Registration Number: NCT04938414
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage.

Detailed Description

Investigate the role of inflammasome and blood coagulation response in human cerebrospinal fluid after subarachnoid hemorrhage (SAH).

1.40 patients with SAH will be included. The CSF will used for ELISA test for inflammatory factors and cogulation factors.

2.CSF obtained from 4 patients with non-neuroloogical disease with 4 addittional SAH patients will be used for Mass Spectrometry

Study Timeline

• Study Start: 2020-12-01
• Status Verified: 2021-06
• Study First Submitted: 2021-06-21
• Study First Submitted QC: 2021-06-23
• Study First Posted: 2021-06-24
• Primary Completion: 2021-08-01
• Study Completion: 2021-10-01
• Last Update Submitted: 2021-12-15
• Last Update Posted: 2022-01-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• SAH patients with modified Fisher Scale 3-4.

Exclusion Criteria

• Patients with history of CNS disease (e.g., stroke, traumatic brain injury, CNS infection) or accompanied by serious comorbidities before SAH onset (e.g., severe coagulation disorders, malignant tumor, uncontrollable heart disease, and hypertension) or other organ dysfunctions within 6 months were excluded from the study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
modified Rankin Scale	evaluated 1day after discharge	modified Rankin Scale (mRS) at discharge. mRS ranging from 0-5, higher represents worse
Length of hospital stay	evaluated 1day after discharge	Length of hospital stay
Glasgow Outcome Scale	evaluated 1day after discharge	Glasgow Outcome Scale (GOS) at discharge, GOS ranging from 0-5, higher represents better

Trial Locations

Locations (1)

Second affiliated hosipital of zhejiang univerisity school of medicine; 🇨🇳 Hangzhou, Zhejiang, China