Combined PECS II and Transversus Plane Blocks Versus Erector Spinae Block in Modified Radical Mastectomy
- Conditions
- Acute Postoperative PainBreast Cancer
- Registration Number
- NCT03903224
- Lead Sponsor
- Assiut University
- Brief Summary
The aim of this study is to compare the total morphine consumption in the first 24 hour postoperative between combined modified pectoralis block (PECS II) and transversus plane block versus erector spinae block in modified radical mastectomy.
- Detailed Description
Breast cancer is the most common malignancy in women in the United States and is second only to lung cancer as a cause of cancer death. Breast surgery is commonly performed as a part of the management of breast cancer, is associated with considerable acute postoperative pain. Ultrasound guided Regional anesthesia is recommended to be a part of multimodal analgesia in order to manage the acute post-operative pain. New techniques are proposed to give adequate control of postoperative analgesia with less opioid needs in the first day postoperative. They include pectoralis nerve modified pectoralis, and erector spinae blocks.
The investigators will compare Modified pectoralis nerve block (Pecs II) plus transversus thoracic muscle plane (TTP) block versus Erector spinae block on morphine consumption during first 24 h following modified radical mastectomy.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 60
- Age 18: 60 years old
- ASA (American Society of Anesthesiologists) physical status I II
- Female patients scheduled for modified radical mastectomy
- Patient refusal or inability to give informed consent
- Subjects with a medical contraindication to regional anesthesia , such as coagulopathy, local infection or an allergy to local anesthetic
- Body mass index (BMI) >35
- Presence of psychiatric diseases
- History of chronic chest wall pain or neuropathic disorders
- Alcohol or drug abuse
- Severe chest wall deformities
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method The total morphine consumption postoperative (mg) The first 24 hours postoperative. Morphine consumption in mg
- Secondary Outcome Measures
Name Time Method Postoperative level of IL6 (interleukin 6) (pg/mL) Two blood samples will be withdrawn from the patient. The first one is immediately preoperative and the second one after 24 hours postoperative Preoperative baseline and postoperative levels of IL6 will be measured (pg/mL)
Postoperative pain score by Verbal numeric rating scale 0, 2, 4, 8, 12, 24 hours postoperatively. Verbal numeric rating scale (VNRS) for postoperative pain monitoring using 11-point where zero equals no pain and 10 equals the worst pain imaginable.
Time to first request analgesia postoperative (min) The first 24 hours postoperatively Time from postoperative period to time of first analgesic request in minutes
Arterial blood gas: Arterial blood gas: Arterial blood gases Before surgery and 24 hours postoperative. Oxygen (mmHg) and carbon dioxide (mmHg)
Trial Locations
- Locations (1)
Assiut University Hospital
🇪🇬Assiut, Egypt
Assiut University Hospital🇪🇬Assiut, Egypt