Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA

Phase 4

Completed

• Conditions: Post Operative Pain; Total Knee Replacement
• Interventions: Drug: morphine and bupivacaine; Drug: spinal morphine and marcaine

• Registration Number: NCT00795223
• Lead Sponsor: Mahidol University

Brief Summary

Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block

Detailed Description

Not available

Study Timeline

• Study Start: 2008-10
• Study First Submitted: 2008-11-20
• Study First Submitted QC: 2008-11-20
• Study First Posted: 2008-11-21
• Primary Completion: 2009-05
• Study Completion: 2009-05
• Status Verified: 2009-09
• Last Update Submitted: 2009-09-28
• Last Update Posted: 2009-09-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Single elective total knee replacement in ASA 1-3 without significant cardiovascular limitation

Exclusion Criteria

• patient at risk in usage COX-2 for post operative pain control

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
4	morphine and bupivacaine	Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine
1	morphine and bupivacaine	Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine
2	spinal morphine and marcaine	Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine
3	morphine and bupivacaine	Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine

Primary Outcome Measures

Name	Time	Method
Global assessment in post operative pain control	Begining of first enrollment in december 2008

Secondary Outcome Measures

Name	Time	Method
Global assessment of post operative pain in 48 HOURS AND SIDE EFFECTS	first enrollment in December 2008

Trial Locations

Locations (1)

Siriraj Hospital; 🇹🇭 Bangkok, Bangkoknoi, Thailand