Comparative Effect of 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for Femoral Nerve Block After Total Knee Replacement
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Global assessment in post operative pain control
研究概览
简要总结
Comparative efficacy of 24 and 48 hours post operative pain control in single total knee replacement between intrathecal bupivacaine with 0.2 or 0.3 mg morphine together with 0.25 or 0.5 % bupivacaine for single femoral nerve block
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 45 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Single elective total knee replacement in ASA 1-3 without significant cardiovascular limitation
排除标准
- •patient at risk in usage COX-2 for post operative pain control
研究组 & 干预措施
1
Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine
干预措施: morphine and bupivacaine (Drug)
2
Injection of 0.3 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine
干预措施: spinal morphine and marcaine (Drug)
3
Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.5% bupivacaine
干预措施: morphine and bupivacaine (Drug)
4
Injection of 0.2 mg morphine with spinal block and perform femoral nerve block with 0.25% bupivacaine
干预措施: morphine and bupivacaine (Drug)
结局指标
主要结局
Global assessment in post operative pain control
时间窗: Begining of first enrollment in december 2008
次要结局
- Global assessment of post operative pain in 48 HOURS AND SIDE EFFECTS(first enrollment in December 2008)