MRI of Infrapatellar Fat Pad in Osteoarthritis

Completed

• Conditions: Osteoarthritis
• Interventions: Radiation: Magnetic resonance imaging

• Registration Number: NCT02829463
• Lead Sponsor: The Third Xiangya Hospital of Central South University

Brief Summary

In this study, the investigators use the clinical documentation and imaging data of MRI to do research. Clinical subjects were divided into two groups: osteoarthritis patients and healthy controls without osteoarthritis. Differences of MRI data were studied between two groups.

Detailed Description

In this study, the investigators applied high precision MRI technique (with as less as a slice thickness of 0.35 mm and without inter-slice gap), and calculated not only the IPFP maximal sagittal area and IPFP volume, but also the quantitated signal, and compared the differences between healthy controls and osteoarthritis patients. This is an observational cross-sectional study without specific interventions to the subjects. MRI is a regular examination in our hospital. And all subjects are included for the reasons of osteoarthritis (need MRI) and healthy controls (pain but not osteoarthritis, also need MRI). The investigator does not assign specific interventions to the subjects of the study.

Study Timeline

• Study Start: 2015-10
• Primary Completion: 2016-07
• Study Completion: 2016-07
• Study First Submitted: 2016-07-07
• Study First Submitted QC: 2016-07-07
• Study First Posted: 2016-07-12
• Results First Submitted: 2016-08-13
• Results First Submitted QC: 2016-08-13
• Results First Posted: 2016-10-07
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-07
• Last Update Posted: 2017-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 121

Inclusion Criteria

• Patients with clinical knee osteoarthritis;
• The healthy controls who require MRI test.

Exclusion Criteria

• Contraindications to magnetic resonance imaging;
• Rheumatoid arthritis patients;
• Gout;
• Hemophilic arthritis;
• Subjects who take non-steroidal anti-inflammatory drugs (NSAIDs);
• Subjects who take lipid-lowering agents;
• Subjects who have the history of knee trauma;
• Subjects who have the history of knee operation;
• Subjects who have the disease of musculoskeletal tumor near knee;
• Subjects who have joint loose bodies.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
osteoarthritis patients	Magnetic resonance imaging	3.0 Tesla Magnetic resonance imaging was analyzed. It's the documentation from the outpatients and inpatients with osteoarthritis. It's not the intervention the study applied, but the subjects' disease demands.
healthy controls	Magnetic resonance imaging	3.0 Tesla Magnetic resonance imaging was analyzed. It's the documentation from the outpatients and inpatients without osteoarthritis. It's not the intervention the study applied, but the subjects' non-osteoarthritis knee symptom demands.

Primary Outcome Measures

Name	Time	Method
Infrapatellar Fat Pad Volume in MRI	collect the data within 24 hours after the subjects did the MRI

Trial Locations

Locations (1)

Jinshen He; 🇨🇳 Changsha, Hunan, China