Plasma glutamine is associated with multiple organ failure in critically ill childre

Not Applicable

Completed

• Conditions: Critical illness; Metabolic and Endocrine - Other metabolic disorders

• Registration Number: ACTRN12613001298707
• Lead Sponsor: Stockholms lans landstng. The Country Council of Stockholm (projects 502033 and 511126).

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-11-22
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

An expected PICU-stay > 24 hours, informed consent and sampling within 48 hours after admittance.

Exclusion Criteria

Absence of informed consent at 48 hours after admittance, failure of sampling or age > 18 years.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To evaluate if low plasma glutamine concentration is associated with the development of multiple organ failure, using the pediatric logistic organ dysfunction score (PELOD) as a multiple organ failure score and as a surrogate marker of mortality.[At admission.]

Secondary Outcome Measures

Name	Time	Method
To longitudinally investigate the development of plasma glutamine levels in critically ill patients and relate this to changes in organ failure, using the pediatric logistic organ dysfunction score (PELOD) as a multiple organ failure score and as a surrogate marker of mortality.. [For this, the patients still in the ICU at day 5 were sampled again. ]