Dental and oral long-term complications of radio- and radio-chemotherapy in the head and neck area

• Conditions: C00-C14; Malignant neoplasms of lip, oral cavity and pharynx

• Registration Number: DRKS00034708
• Lead Sponsor: Medizinische Hochschule Hannover

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-07-26
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Tumor in the oral cavity, oropharynx, hypopharynx or larynx (corresponding to ICD codes C00 - C14),
Primary or adjuvant radio- or radio-chemotherapy with curative therapy objective,
German language skills,
Informed Consent

Exclusion Criteria

Palliative tumor therapy;
Previous radio therapy in the head and neck area;
Pregnancy/breastfeeding period;
Allergies to materials used;
Small residual dentition (<10);
Carious lesions not treated in the dental pre-treatment phase (ICDAS 3, 4, 5, 6);
Deep, inflamed, periodontal pockets;
Hyposalivation before the start of the study (unstimulated salivary flow rate < 0.1 ml/min or stimulated salivary flow rate < 0.7 ml/min; check during the baseline examination before the biopsy with subsequent exclusion if necessary);
Serious blood clotting disorder;
Known wound healing disorder.

Study & Design

• Study Type: observational
• Study Design: Not specified