Metabolic effects of morning light
Completed
- Conditions
- type 2 diabetes10018424
- Registration Number
- NL-OMON39953
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 8
Inclusion Criteria
- age 18-50 years
- male sex
- BMI 18-25
- fasting plasma glucose < 5.6 mmol/L
- habitual wake-up time between 7:00 and 9:00
Exclusion Criteria
- medication interfering with glucose metabolism or neuronal synaptic transmission (corticosteroids, anti-depressants, anti-epileptic medication, other psychotropic drugs, anti malarials)
- gastro-intestinal or metabolic disease that will interfere with digestion or metabolism
- neuropsychiatric illness including severe depression
- epilepsy
- hypertension
- ophthalmological abnormalities
- lactose intolerance
- soy allergy
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Postprandial glucose excursions, and expression of metabolic genes in adipose<br /><br>tissue.</p><br>
- Secondary Outcome Measures
Name Time Method <p>postprandial insulin excursions<br /><br>- postprandial free fatty acid (FFA) excursions<br /><br>- postprandial triglyceride levels<br /><br>- morning glucocorticoid increase<br /><br>- morning salivary melatonin decrease<br /><br>- resting energy expenditure (REE)<br /><br>- measurements of autonomic balance:<br /><br>- skin temperature decrease<br /><br>- heart rate variability</p><br>