Microvascular Resistance Reserve Assessment Derived from Absolute flow and Resistance by PET and CT

Phase 4

Conditions: coronary microvascular dysfunction
dysfunction of small arteries of the heart
10011082

Registration Number: NL-OMON56637

Lead Sponsor: Amsterdam UMC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 40

Inclusion Criteria

1. Referred for ICA because of suspected CAD
2. No documented prior history of CAD
3. Age >=18 and <=80 years old

Exclusion Criteria

1. Unstable CAD, Non-ST-Elevation Myocardial Infarction (NSTEMI), ST-Elevation
Myocardial Infarction (STEMI), cardiogenic shock or hemodynamically unstable
patients 2. Patients with previous coronary artery bypass (CABG) surgery, PCI
or myocardial infarction (MI) 3. Tortuous or calcified coronary arteries, if
known 4. Coronary arteries with a small caliber (<2,5 mm), if known 5. Atrial
fibrillation, second or third degree atrioventricular block or severe
conduction disturbances with an indication for temporary or permanent pacing 6.
History of severe COPD or chronic asthma 7. Renal failure ( i.e. eGFR < 30
mL/min) 8. Use of sildenafil (Viagra) or dipyramidol (Persantin) that cannot be
terminated 9. Contra-indications for β-blockers 10. Allergic reaction to
iodized contrast 11. Pregnancy 12. Inability to understand and give informed
consent

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint will be the correlation and agreement between non-invasive<br /><br>and invasive. To achieve our study objective, MRR calculated by PET and FFRCT<br /><br>will be compared to invasively measured MMR.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secondary endpoint will be correlation and agreement between non-invasively<br /><br>and invasively measured resting and hyperemic resistance.</p><br>