RECOVERY OF MICROVASCULAR MYOCARDIAL RESISTANCE AFTER ST ELEVATION MYOCARDIAL INFARCTION AND ITS RELATION TO OUTCOME

Completed

Conditions: acute myocardial infarction
10011082

Registration Number: NL-OMON44383

Lead Sponsor: Catharina-ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 50

Inclusion Criteria

* Patients with STEMI * 12 hours and with ST deviation * 5 mm. Who have one or more other lesions mandating FFR or PCI in de following days after PCI of the culprit artery;INCLUSION CRITERIA
* Age between 18 and 75 years
* Presentation within 12 hours after the onset of complaints
* Acute ST-elevation myocardial infarction with a total ST segment deviation *5 mm
* Able to give and understand informed consent
* Culprit lesion in a proximal or mid-segment of one of the major coronary arteries (diameter *2,5 mm), which is stented successfully
* Stable condition after stenting
* One or more additional lesions in one or more different coronary arteries, mandating FFR measurement +/- PPCI during the subacute phase

Exclusion Criteria

* Age less than 18 years or more than 75 years
* Cardiogenic shock or pre-shock
* Patients with previous myocardial infarction in the culprit artery or with previous bypass surgery
* Very tortuous or calcified coronary arteries
* Long or complex PCI
* Severe concomitant disease or conditions with a life expectancy of less than 1 year
* Inability to understand and give informed consent
* Known myocardial diseases such as moderate or severe left ventricular hypertrophy or cardiomyopathy
* Pregnancy
* Severe conduction disturbances necessitating implantation of a temporary pacemaker
* Contraindications for MRI (claustrophobia, ferromagnetic metal fragments in the body)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>evaluate changes in myocardial resistance over time in STEMI patients, both in<br /><br>the early stage and the subacute phase. It is hypothesized that patients can be<br /><br>divided into 3 groups:<br /><br>A. Patients with an (almost) normal resistance and flow immediately after PPCI<br /><br>B. Patients with still elevated resistance and decreased flow immediately after<br /><br>PPCI, but (partial) recovery in the next days<br /><br>C. Patients with elevated resistance and decreased flow immediately after PPCI<br /><br>which do not recover at all.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The course of such changes and recovery of the microcirculation will be<br /><br>correlated to long-term outcome as assessed by MRI measurements and final<br /><br>infarct size<br /><br><br /><br>1) Long term outcome<br /><br>2) final infarct size on MRI</p><br>