Image derived coronary microvascular resistance and flow reserve in ANOCA

Completed

• Conditions: Coronary microvascular dysfunction / microvasculair lijden; 10011082

• Registration Number: NL-OMON50485
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2022-05-02
• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

* Patient >=18 years of age
* Patient planned for clinically-indicated coronary vasoreactivity testing
because of anginal complaints and nonobstructive coronary artery disease
* Able and willing to provide informed consent

Exclusion Criteria

* Patients with an estimated glomurar filtration rate of <30ml/min
* Patients with a known left ventricular ejection fraction <35%
* Active pregnancy
* Contrast allergy

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Patients will be categorized as negative or positive for endothelial<br /><br>independent microvascular dysfunction based on the thermodilution measurements.<br /><br>Microvascular dysfunction is defined as an abnormal CFR and/or IMR. The primary<br /><br>study parameter will be the diagnostic accuracy of image derived IMR and CFR<br /><br>for endothelial independent microvascular dysfunction based on thermodilution<br /><br>measurements. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>