Comparing coronary microcirculatory resistance by magnetic resonance imaging to invasive measurement of microcirculatory resistance

Not Applicable

• Conditions: Angina; Coronary microvascular disease; Ischaemia and no obstructive coronary artery disease; Cardiovascular - Coronary heart disease

• Registration Number: ACTRN12621000270819
• Lead Sponsor: Professor Martin Ugander

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-03-11
• Last Update Posted: 28 February 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Patients with non-obstructive coronary artery disease who have had comprehensive invasive coronary physiology assessment with no evidence of microvascular disease

Exclusion Criteria

Obstructive coronary artery disease
Haemodynamic instability from cardiogenic shock
Severe asthma
Heavily calcified or tortuous vessels
Inability to provide informed consent

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The standardised distance (Z score) for the coronary resistance index by magnetic resonance imaging (MRI) between healthy volunteers and patients with increased index of microcirculatory resistance (IMR), compared to the Z score for IMR between the same groups, using the paired t-test or non-parametric test as appropriate.[Within 2 weeks after invasive coronary physiology assessment ]

Secondary Outcome Measures

Name	Time	Method
CRI assessed by MRI [Within 2 weeks of enrolment ]