NCT03630900已完成不适用
5% O2 or Lower is the Ideal Tension for Culturing Human Embryo Development From Day 3 Onward
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 487
- 试验地点
- 4
- 主要终点
- Ongoing Implantation rate
研究概览
简要总结
Myriads of elements affect human embryo culture in vitro. These include, but not limited to, air quality, culture media, culture temperature, incubator humidity, pH, and O2 levels. O2 tension has been thoroughly investigated and, to date, 5% O2 level is superior to 20%. Reports showed that lowering the O2 from Day 3 of embryo culture seems to be physiological.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ICSI cycles undergoing their first ICSI attempt
排除标准
- •ICSI cycles with a previous failure
研究组 & 干预措施
Sequential O2 culture (5% then 2.5%)
Experimental
Embryo culture from day 0 to 3 in 5% O2 then split to either 5% or 2.5% O2 until Day 5 or 6.
干预措施: Sequential O2 Culture (Other)
5% O2 culture
No Intervention
结局指标
主要结局
Ongoing Implantation rate
时间窗: three months
number of sacs with a heartbeat after week twelve of gestation
次要结局
- human embryo development in vitro(three months)
- clinical and ongoing pregnancies(three months)
研究者
Muhammad Fawzy
IVF Lab Director
Ibn Sina Hospital
研究点 (4)
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