Intervention study on the effect of oyster mushrooms as part of a meal on glucose and lipid metabolism, hunger and satiety in adults with impaired glucose tolerance

Not Applicable

• Conditions: R73.0; Abnormal glucose tolerance test

• Registration Number: DRKS00015244
• Lead Sponsor: Hochschule Niederrhein, Fachbereich Oecotrophologie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-08-09
• Study Completion: 2019-02-19
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

Impaired glucose tolerance according to national and international guidelines (2-h-glucose concentration after OGTT between 140-199 mg/dl), nonsmoker for at least 3 months, written informed consent

Exclusion Criteria

Intake of drugs that may affect primary or secondary outcome measures; intake of antibiotics within the last 6 weeks; hepatic and gastrointestinal diseases accompanied with diarrhea and malabsorption; allergies, intolerances and aversions against mushrooms and components of the test meal; cardiac pacemaker or other implantable electronic devices; pregnancy/lactation; planned changes in lifestyle (e.g. by diet); regular consumption of foods or supplements rich in ß-glucans

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose-AUC (Area under the curve), based on glucose concentration in sodium fluorid plasma which will be determined before and 15, 30, 45, 60, 90, 120, 180 and 240 min after meal consumption

Secondary Outcome Measures

Name	Time	Method
Gucose metabolism (insulin in serum, GIP and GLP-1 in EDTA-plasma), lipid metabolism (triglycerides and non-esterified free fatty acids in serum), hunger and satiety (determined by means of visual analog scales; ghrelin in EDTA-plasma); <br>determination before as well as 15, 30, 45, 60, 90, 120, 180 and 240 min after meal consumption