Single-dose intravenous dexamethasone reduces Post-operative pain in multiple level lumbar spine surgery , randomized controlled trial

Phase 4

Recruiting

• Conditions: Post operative pain in multiple level spine surgery (Decompressive laminectomy + Instrumentation + Posterolateral fusion) for degenerative spine patients; spine surgery; Dexamethasone; reduce post operative pain

• Registration Number: TCTR20210330004
• Lead Sponsor: Orthopedics department of Khon kaen Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-03-30
• Study Completion: 2021-07-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

Lumbar stenosis between L2-S1 level in Degenerative Group. Diagnosis by
1. History of radiculopathic pain , muscle weakness , Back pain with Failed conservative Treatment or Progressive neuro deficit
2. Physical examination were detected weakness of key motor muscle and decrease sensation test (dermatome)
3. MRI LS spine was detected Stenosis of Lumbar spine level

Exclusion Criteria

1.Tuberculosis/Bacterial Spine infection , Trauma and spine metastasis
2.Patient with upper Gastrointestinal bleeding
3. Renal insufficiency (GFR < 30 ml/min/1.73m2) , Liver cirrhosis
4. Poor controlled Diabetes mellitus
5. allergic to Glucocorticoids drug
6. intake some Glucocorticoids drug (IV ,IM , Oral) in 1 month before surgery
7. Recent systemic infection
8. Refuse to participate in research

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain score at 48 hours after end of surgery pain score picture

Secondary Outcome Measures

Name	Time	Method
total morphine consumption 0-48 hours after end of surgery total dose of morphine(mg)/Body weight(Kg)