Neuropeptides in the Humane Intra- og Extracerebral Circulation.
- Conditions
- HealthyMigraine
- Registration Number
- NCT00399633
- Lead Sponsor
- Danish Headache Center
- Brief Summary
The study aim at examining whether Sumatriptan changes the plasma values of the neuropeptides vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.
- Detailed Description
The study is meant to give a better understanding of the basic mechanisms behind migraine, and a better understanding of the effects of sumatriptan on the trigemino vascular system.
The endpoints are changes in the plasma values of the neuropeptides vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase activating peptide (PACAP) and the prostanoids 6-keto-PGF1α, and PGE2, PGD2 og PGF2α.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- healthy volunteers
- 18-50 years,
- 50-100 kg.
- Fertile women must use birth control.
- All primary types of headache
- Daily intake of medicine except birth control
- Pregnancy
- Hypertension
- Hypotension
- other chronic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Blood concentration of vasoactive intestinal polypeptide (VIP), calcitonin gene-related protein (CGRP), pituitary adenylate cyclase activating peptide (PACAP,) and the prostanoids 6-keto-PGF1α, PGE2, PGD2 and PGF2α, sampled from different venous catheters.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Danish Headache Center
🇩🇰Glostrup, Copenhagen, Copenhagen, Denmark