NCT02376738已完成不适用
Regional Activation of Leukocytes in Coronary Artery Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 97
- 试验地点
- 1
- 主要终点
- Assess the level of leukocyte activation in different vascular beds, by measuring monocyte CD11b and neutrophil CD11b and CD66b in blood obtained from the left and right coronary artery, the abdominal aorta, the femoral artery and a peripheral vein
研究概览
简要总结
This study aims to evaluate the role of leukocyte activation in coronary artery disease
详细描述
- The primary aim of REAL CAD is to determine regional differences of leukocyte activation in different vascular beds in vivo.
- The secondary aim is to investigate differences in leukocyte activation between diabetic and CAD subjects and patients suffering from both.
- The third aim is to investigate the relationship between complement components, triglycerides and leukocyte activation markers in order to gain more insight into the causative processes leading to activation of leukocytes.
- The fourth aim is to get more insight in the MBL genotypes and serum levels of CAD and/or diabetic patients and the 'healthy' groups included in our study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects scheduled to undergo a coronary catheterization
- •Provide written informed consent
- •Aged >18 and <75 years
- •BMI < 35 kg/m2
排除标准
- •Emotionally and intellectually not capable to decide about participation in the study and the consequences of participation. Subjects who are not able to understand the patient information
- •CRP > 20 mg/l
- •Unstable angina pectoris
- •CABG or PTCA during the last 6 months
- •Alcohol use > 2 units/day
- •Aberrations in kidney, liver and thyroid function
- •Use of any experimental medication within 6 months of the catheterization
- •The use of immunosuppressive drugs
结局指标
主要结局
Assess the level of leukocyte activation in different vascular beds, by measuring monocyte CD11b and neutrophil CD11b and CD66b in blood obtained from the left and right coronary artery, the abdominal aorta, the femoral artery and a peripheral vein
时间窗: Baseline
次要结局
- To investigate the predictive value of leukocyte activation markers CD11b and CD66b in different vascular regions in the prediction of future coronary events, by measuring these markers at baseline(6 years follow-up)
- Investigate differences in leukocyte activation between patients with and without diabetes mellitus or coronary artery disease by comparing the level of monocyte CD11b and neutrophil CD11b and CD66b(Baseline)
研究者
M.A. de Vries
PhD Student
Sint Franciscus Gasthuis
研究点 (1)
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