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临床试验/NCT02376738
NCT02376738已完成不适用

Regional Activation of Leukocytes in Coronary Artery Disease

Sint Franciscus Gasthuis1 个研究点 分布在 1 个国家目标入组 97 人开始时间: 2007年7月最近更新:
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适应症

试验速览

阶段
不适用
状态
已完成
入组人数
97
试验地点
1
主要终点
Assess the level of leukocyte activation in different vascular beds, by measuring monocyte CD11b and neutrophil CD11b and CD66b in blood obtained from the left and right coronary artery, the abdominal aorta, the femoral artery and a peripheral vein
研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

This study aims to evaluate the role of leukocyte activation in coronary artery disease

详细描述

  1. The primary aim of REAL CAD is to determine regional differences of leukocyte activation in different vascular beds in vivo.
  2. The secondary aim is to investigate differences in leukocyte activation between diabetic and CAD subjects and patients suffering from both.
  3. The third aim is to investigate the relationship between complement components, triglycerides and leukocyte activation markers in order to gain more insight into the causative processes leading to activation of leukocytes.
  4. The fourth aim is to get more insight in the MBL genotypes and serum levels of CAD and/or diabetic patients and the 'healthy' groups included in our study.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 75 Years（Adult, Older Adult）
性别
All
接受健康志愿者
否

入选标准

  • •Subjects scheduled to undergo a coronary catheterization
  • •Provide written informed consent
  • •Aged >18 and <75 years
  • •BMI < 35 kg/m2

排除标准

  • •Emotionally and intellectually not capable to decide about participation in the study and the consequences of participation. Subjects who are not able to understand the patient information
  • •CRP > 20 mg/l
  • •Unstable angina pectoris
  • •CABG or PTCA during the last 6 months
  • •Alcohol use > 2 units/day
  • •Aberrations in kidney, liver and thyroid function
  • •Use of any experimental medication within 6 months of the catheterization
  • •The use of immunosuppressive drugs

结局指标

主要结局

Assess the level of leukocyte activation in different vascular beds, by measuring monocyte CD11b and neutrophil CD11b and CD66b in blood obtained from the left and right coronary artery, the abdominal aorta, the femoral artery and a peripheral vein

时间窗: Baseline

次要结局

  • To investigate the predictive value of leukocyte activation markers CD11b and CD66b in different vascular regions in the prediction of future coronary events, by measuring these markers at baseline(6 years follow-up)
  • Investigate differences in leukocyte activation between patients with and without diabetes mellitus or coronary artery disease by comparing the level of monocyte CD11b and neutrophil CD11b and CD66b(Baseline)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

M.A. de Vries

PhD Student

Sint Franciscus Gasthuis

研究点 (1)

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