MedPath

Spray vs EMLA Cream on Pain During Intra-articular Injection

Phase 4
Conditions
Adhesive Capsulitis of the Shoulder
Interventions
Device: Walter Ritter Ethyl Chloride Spray
Other: Placebo Spray
Other: Placebo Cream
Registration Number
NCT03484832
Lead Sponsor
Soonchunhyang University Hospital
Brief Summary

All participants are randomly allocated to the spray group, EMLA group and placebo group. In spray group, participants receive an application of placebo cream at the needle electrode insertion site 60 minutes before needle insertion, and a self adhering dressing is placed over the site. After 60 minutes, the dressing and cream are removed from the site, then the insertion site is sprayed from a distance of 30 cm for 5 seconds or until the skin was blanched, then intra-articular injection of shoulder is performed. Immediately after injection, participants are asked to fill out the visual analog scale for injectional pain, five point Likert scale for satisfaction about the topical anesthesia. In EMLA group, participants receive an EMLA cream and placebo spray. In placebo group, participants receive a placebo cream and placebo spray.

Detailed Description

All participants are randomly allocated to the spray group, EMLA group and placebo group.

In spray group, participants receive an application of placebo cream at the needle electrode insertion site 60 minutes before needle insertion, and a self adhering dressing is placed over the site. After 60 minutes, the dressing and cream are removed from the site, then the insertion site is sprayed using ethyl chloride spray (Walter Ritter GmbH and Co., Hamburg, Germany) from a distance of 30 cm for 5 seconds or until the skin was blanched, then intra-articular injection of shoulder is performed. Immediately after injection, participants are asked to fill out the visual analog scale for injectional pain, five point Likert scale for satisfaction about the topical anesthesia.

In EMLA group, participants receive an application of EMLA cream at the needle electrode insertion site 60 minutes before needle insertion, and a self adhering dressing is placed over the site. After 60 minutes, the dressing and cream are removed from the site, then the insertion site is sprayed using placebo spray (Evain Eau Minerale Naturelle, a pure water spray with hydrocarbon propellant), then intra-articular injection of shoulder is performed. Immediately after injection, participants are asked to fill out the same scales.

In placebo group, participants receive a placebo cream and placebo spray.

Recruitment & Eligibility

Status
UNKNOWN
Sex
All
Target Recruitment
63
Inclusion Criteria
  • Who had a normative schedule of intra-articular injection of shoulder
Exclusion Criteria
  • those who refused to participate, those who were unable to understand a visual analog scale or a Likert scale, those with a history of an allergic reaction to vapocoolant spray or lidocaine, those with a history of cold intolerance (eg, Raynaud syndrome), those who took pain medications or had used topical anesthetics within the previous 24 hours, those with prior history of intra-articular injection of shoulder, those who exhibited an abnormal shoulder sensation on neurologic examination

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Spray groupPlacebo CreamUsing Walter Ritter Ethyl Chloride Spray and placebo cream
Spray groupWalter Ritter Ethyl Chloride SprayUsing Walter Ritter Ethyl Chloride Spray and placebo cream
EMLA groupPlacebo SprayUsing EMLA cream and placebo spray
Placebo groupPlacebo SprayUsing placebo cream and placebo spray
Placebo groupPlacebo CreamUsing placebo cream and placebo spray
EMLA groupEMLA CreamUsing EMLA cream and placebo spray
Primary Outcome Measures
NameTimeMethod
Visual analog scale for injection painWithin 5 minute

The 100-mm VAS consisted of a 100-mm horizontal line labeled ''no pain'' at the left and ''worst pain imaginable'' at the right.

Secondary Outcome Measures
NameTimeMethod
Five point Likert scale for preferences for future usageWithin 5 minute

The five-point Likert scale (1, strongly agree; 2, agree; 3, undecided; 4, disagree; and 5, strongly disagree) is used to answer the question: "Would you use the topical anesthetic methods applied today again if the shoulder intra-articular injection is repeated in the future?"

Five point Likert scale for participant's satisfactionWithin 5 minute

The five-point Likert scale (1, strongly agree; 2, agree; 3, undecided; 4, disagree; and 5, strongly disagree) is used to answer the question: ''Are you satisfied with the topical anesthetic methods used before performing the shoulder intra-articular injection?''

Trial Locations

Locations (1)

Soonchunhyang University Hospital, Bucheon

🇰🇷

Bucheon, Gyeonggido, Korea, Republic of

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