Chest muscle function in patients during removal from ventilator in ICU

Not yet recruiting

Conditions: Acute and chronic respiratory failure,

Registration Number: CTRI/2022/03/040965

Lead Sponsor: Souvik Chaudhuri

Brief Summary: Mechanically ventilated patients who are fitting the inclusion and exclusion criteria will be included for this study. The duration of spontaneous breathing trial (SBT) will be 120 minutes as per the protocol at our institute. Just before initiation of SBT, the patient will be evaluated by bedside ultrasound for the lung ultrasound score for presence of pulmonary oedema, cardiac function ( systolic and diastolic function). Patients who tolerate at least 30 minutes of SBT will be evaluated for lung ultrasound for evidence of weaning induced pulmonary oedema (WIPO), bedside echocardiography (systolic and diastolic dysfunction) and parasternal muscle thickening and parasternal muscle thickening fraction. Diaphragmatic excursion and diaphragmatic thickening fraction will also be noted.

At the end of 120 minutes of SBT, whether or not the patients are getting successfully off ventilator support as per the treating intensivist, will be noted.

The patients who fail even 30 minutes of SBT, the following parameters will be noted after the patient is put back on previous ventilatory support as per the treating intensivist- lung ultrasound for evidence of pulmonary oedema, systolic and diastolic function as per echocardiography. The patients who fail SBT for the first time, will be followed for the subsequent 3 SBT for the same parameters as outlined above for the first SBT. The number of SBT required for successful weaning from ventilator will be noted.

Patients who are removed from ventilator after SBT success at 120 minutes will be followed for next 48 hours to see if they require invasive ventilator support/ intubation again.

Outcome of the ICU stay at 28 days will be noted - survival or mortality.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 145

Inclusion Criteria

Patients who were mechanically ventilated in ICU and meet the following criteria will be put on SBT for weaning will be included.
Following will be the criteria to consider for weaning in the ICU which is used by any intensivist at our institute: 1.
Fraction of inspired oxygen (FiO2 < 0.5) 2.
Positive end expiratory pressure (PEEP) â‰¤ 5cmH2O 3.
Partial pressure of oxygen in arterial blood (PaO2)/FiO2 > 150 mmHg 4.
Respiratory rate < 35/minute 5.
Tidal volume >5mL /kg, 6.
Minute ventilation < 10L/min 7.
No abnormality in electrolyte parameters, absence of hemodynamic instability, resolution of the initial cause of ventilator requirement and patients awake with the ability to cough.

Exclusion Criteria

Patients with chest wall abnormalities, 2.
Distorted chest wall anatomy, 3.
Patients with any known neuromuscular weakness, 4.
Patients with any known diaphragmatic disorders 5.
Pregnant patients, 6.
Patients with known cardiac dysfunction on initial ECHO during hospital admission 7.
Any patient in whom the SBT is aborted even before 30 minutes duration as deemed by the intensivist will be excluded.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Successful weaning from ventilator	48 hours after removal of ventilator

Secondary Outcome Measures

Name	Time	Method
Survival of ICU stay	28 days from day of admission to ICU

Trial Locations

Locations (1): Kasturba Medical College and Kasturba Hospital, Manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba Medical College and Kasturba Hospital, Manipal
🇮🇳Udupi, KARNATAKA, India
Souvik Chaudhuri
Principal investigator
9937178620
souvik.chaudhuri@manipal.edu