Pilot study investigating the relationship between neurocognitive function, radiotherapy and cerebral white matter microstructure in low grade glioma patients by using MRI diffusion tensor imaging

Completed

• Conditions: brain tumor; Low grade glioma; 10029211

• Registration Number: NL-OMON46061
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

- WHO grade II or III glioma
- Radiotherapy received and still in follow-up, both in the UMCG

Exclusion Criteria

- Younger than 18 years at the time of glioma diagnosis
- Disease progression requiring additional treatment since radiotherapy
- MRI contra-indicated

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is the correlation between neurocognitive function and DTI<br /><br>abnormalities seen on MRI, expressed in fractional anisotropy (FA). Both will<br /><br>be analyzed as a continuous variable. DTI parameters and cognition will also be<br /><br>related to other MRI parameters.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>