Will steam inhalation of drug dexmedetomidine before surgery improve surgery conditions, control BP and heart rate during anesthesia breathing tube placement and surgery as compared to steam inhaled combination dexmedetomidine-lignocaine and saline in pituitary surgery through nose route.
Not Applicable
- Conditions
- Health Condition 1: E220- Acromegaly and pituitary gigantismHealth Condition 2: E221- HyperprolactinemiaHealth Condition 3: E230- HypopituitarismHealth Condition 4: E236- Other disorders of pituitary glandHealth Condition 5: E240- Pituitary-dependent Cushings disease
- Registration Number
- CTRI/2022/03/041234
- Lead Sponsor
- Dr Ranganatha Praveen C S
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
ASA (American Society of Anaesthesiology) 1 and 2
Surgery for pituitary tumors via Transnasal trans sphenoidal surgery (TNTS) route
Glasgow Coma Score(GCS) 15
Cushings and Acromegaly without cardiac abnormality
Exclusion Criteria
GCS <15
Raised ICP(Intracranial pressure)
Pregnant & nursing mothers, patients < 18 years or more than 60 years.
Pituitary apoplexy, Cushings and acromegaly with cardiac abnormality.
ASA (American Society of Anaesthesiology) 3,4 and 5
Concomitant severe medical illness like decompensated heart failure, advanced liver disease, renal failure. History of allergy and previous nasal surgery
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the effects of nebulized dexmedetomidine-lignocaine combination, nebulized dex-medetomidine in saline and nebulized saline alone on intra operative surgical conditions and hemodynamic fluctuations in TNTS pituitary surgeryTimepoint: Surgical field assesment-Beginning of surgery, every 15 minutes from start of surgery till the tumour is reached. Hemodynamic assessment-Baseline,Beginning of surgery,every minute after packing soaked adrenaline gauze, at insertion of the endoscope and 3 minutes later, at the start of mucosal dissection and then every minute for 5 minutes, every 10 minutes for 1 hour, half- hourly for subsequent hours during surgery.
- Secondary Outcome Measures
Name Time Method To compare the effects of nebulized dexmedetomidine-lignocaine combination, nebulized dex-medetomidine in saline and nebulized saline alone on Hemodynamic responses to intubation, extubation, post operative pain, post operative throat discomfort due to throat pack and total Propofol/fentanyl/labetalol use.Timepoint: Haemodynamics- Baseline, after nebulisation,intubation, immediately post intubation and every minute for next 5 minutes and every 2 minutes for next 5 minutes upto 10 minutes after intubation, at extubation and 5minutes after extubation.All these time points are done in the operation theatre.Total anesthetic agents used at different stages will be individually calculated at the end of the surgery. <br/ ><br>Post operative pain and throat discomfort-assessed within 24 hrs following surgery.