Revascularisation of Autotransplanted Teeth

Not Applicable

Completed

• Conditions: Pulp Canal Obliteration; Endodontic Disease
• Interventions: Procedure: Autotransplantation and Apicoectomy

• Registration Number: NCT05267249
• Lead Sponsor: Medical University of Graz

Brief Summary

Retrospective Analysis of a Study cohort that experienced autotransplantation of mature teeth with simultaneous root end resection

Note: The study was registered on Clinicaltrials.gov after termination of study.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-08-06
• Status Verified: 2022-02
• Primary Completion: 2022-02-01
• Study Completion: 2022-02-15
• Study First Submitted: 2022-02-23
• Study First Submitted QC: 2022-02-23
• Last Update Submitted: 2022-02-23
• Study First Posted: 2022-03-04
• Last Update Posted: 2022-03-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Male and female consenting and judicious young people and adults
• Written consent of the participant and, if applicable, of the legal guardian after education
• Planned tooth transplantation with advanced or completed root growth

Exclusion Criteria

• Contraindications for magnetic resonance imaging (MRI): (pronounced metal restorations, running orthodontics with metal, fixed appliance in the target jaw)
• Current or past antiresorptive therapy with bisphosphonates
• Further anamnestic general or local risk situation, among others: Anti-angiogenic therapy, History of local radiation therapy, severe coagulation disorder, unadjusted diabetes mellitus, malignant diseases
• Acute gingivitis or advanced periodontitis
• Participation in an ongoing drug trial (various drugs may distort the result, such as bisphosphonates, cortisone, chemotherapeutics, angiogenesis inhibitors)
• heavy smokers (> 10 per day)
• Acute or chronic infections (osteomyelitis) at the surgical site
• metabolic diseases (diabetes, hyperparathyroidism, osteomalacia)
• Severe kidney dysfunction, severe liver disease
• Patients with high-dose corticosteroid therapy
• prolonged corticosteroid or radiotherapy in the oral cavity
• autoimmune diseases
• Pregnant or breastfeeding women

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Autotransplantation	Autotransplantation and Apicoectomy	Autotransplantation and apicoectomy of mature teeth

Primary Outcome Measures

Name	Time	Method
Survival	1 year	Tooth survival

Secondary Outcome Measures

Name	Time	Method
Revascularisation	1 year	Occurrence of Revascularisation

Trial Locations

Locations (1)

Medical University of Graz; 🇦🇹 Graz, Styria, Austria