Role of Tranexamic acid in reducing blood loss in total hip replacement surgeries
Not Applicable
- Conditions
- Health Condition 1: M249- Joint derangement, unspecified
- Registration Number
- CTRI/2018/08/015421
- Lead Sponsor
- AIIMS Raipur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Adult patients, 18 â?? 65 years of either sex with ASA grade I and II undergoing primary elective unilateral hip joint arthroplasty by same surgeon.
Exclusion Criteria
Patients with
a) The absence of written informed consent
b) Bilateral arthroplasties
c) Complicated primary total hip arthroplasty with previous osteotomy, simultaneous fracture fixation, implant removal or bone grafting,
History of thromboembolic diseases,
d) The presence of clotting disorder or current treatment with an antiplatelet agent, anticoagulant or deep vein thrombosis (DVT) prophylaxis in the perioperative period,
e) Renal disease
f) History of the previous allergy to TXA.
g) History of labile or uncontrolled hypertension
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method a.Drop in Hct after 24 hours <br/ ><br>b.Blood transfusion requirement in the first 24 hoursTimepoint: Pre-op Hb/Hct: <br/ ><br>Post-op Hb/Hct: <br/ ><br>Immediately after surgery: <br/ ><br>24 hours after surgery: <br/ ><br>48 hours after surgery: <br/ ><br>Drain output: <br/ ><br>3 hours after surgery: <br/ ><br>6 hours after surgery: <br/ ><br>12 hours after surgery: <br/ ><br>24 hours after surgery: <br/ ><br>
- Secondary Outcome Measures
Name Time Method c.Decrease in inflammatory markers (IL6 and D-dimer) after 12 hours compared to the baseline <br/ ><br>d.Complications if any during the stay in hospital <br/ ><br>Timepoint: The Quantitative value of IL6: Before the start of surgery and 12 hours after surgery: <br/ ><br>The Quantitative value of D-dimer: Before the start of surgery and 12 hours after surgery: <br/ ><br>