Application of Combined Lumbar Plexus and Sciatic Nerve Block

Phase 4

Completed

• Conditions: Anesthesia
• Interventions: Procedure: Nerve block; Procedure: Combined spinal and epidural anesthesia; Drug: Ropivacaine; Drug: Bupivacaine

• Registration Number: NCT02084368
• Lead Sponsor: Guangzhou General Hospital of Guangzhou Military Command

Brief Summary

The research is to study the effectiveness and safety of combined lumbar plexus and sciatic nerve block by the guide of peripheral nerve stimulator (PNS) in unilateral knee replacement.There have be some papers which supported that combined lumbar plexus and sciatic nerve block may be more suitable for the old men.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2014-02
• Study Completion: 2014-02
• Study First Submitted: 2014-03-06
• Study First Submitted QC: 2014-03-10
• Study First Posted: 2014-03-12
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-10
• Last Update Posted: 2014-09-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

1. Patients of American Association of anesthetists（ASA）Grade 1、2 or 3
2. Aged between 18 and 85 years
3. Undergoing elective total knee replacement.

Exclusion Criteria

1. Mental illness can not match
2. Nerve block, epidural anesthesia contraindicated
3. People who have Slow-type arrhythmias
4. History of chronic headaches and long-term use of analgesic drugs
5. People who were postoperative consciousness, language or hearing impaired

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Nerve block	Nerve block	Patients in this group were assigned to receive lumbar plexus block and sciatic nerve block guided by PNS.
combined spinal and epidural anesthesia	Combined spinal and epidural anesthesia	Combined spinal and epidural anesthesia were performed in patients of this group.
Nerve block	Ropivacaine	Patients in this group were assigned to receive lumbar plexus block and sciatic nerve block guided by PNS.
combined spinal and epidural anesthesia	Bupivacaine	Combined spinal and epidural anesthesia were performed in patients of this group.

Primary Outcome Measures

Name	Time	Method
Maintenance time of sensory and motor nerve block	up to 24h after operation	from the end of injection of local anesthetic drug up to 24h after operation

Secondary Outcome Measures

Name	Time	Method
The change of hemodynamics	0, 5, 10, 20, 30, 60 min after injection	the changes of SBP and DBP at 0, 5, 10, 20, 30, 60 min after injection

Trial Locations

Locations (1)

Guangzhou Military Region General Hospital, Department of Anesthesiology; 🇨🇳 Guangzhou, Guangdong, China