Influence of long-term administration of fluoxetine on cerebral threshold and muscle activity patterns in chronic stroke patients.

Phase 3

• Conditions: cerebral vascular accident; stroke; 10007963

• Registration Number: NL-OMON30510
• Lead Sponsor: Medisch Spectrum Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 34

Inclusion Criteria

First ever ischemic cortical/subcortical ischemic stroke, confirmed by CT or MRI; more than 6 months after stroke; age > 18

Exclusion Criteria

Patients suffering from another neurological disease; uncompensated hemineglect or cognitive disabilities; epilepsy, or first epileptic insult post stroke; patients with first grade relatives suffering from epilepsy; pregnancy; pacemaker; pathological heart rhythms disorders; use of antidepressants.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are:<br /><br>- Motor threshold (MT) to measure excitability<br /><br>- stimulus response curve (SRC) to measure excitability<br /><br>- root mean square (RMS) of the electromyogram (EMG) of the lower part of the<br /><br>arm, to measure muscle activation.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary study paramters are:<br /><br>- activation of frequencybands in the brain;<br /><br>- phase-synchronization in the brain, to measure communication between<br /><br>different areas;<br /><br>- motor function.</p><br>