NCT04252027已完成不适用
Therapeutic Drug Monitoring of Fluconazole in Critically Ill Patients: a Longitudinal Follow-up of Trough Levels
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 43
- 试验地点
- 1
- 主要终点
- Exposure to fluconazole (trough levels)
研究概览
简要总结
This prospective study will research the exposure and its variability to fluconazole after longitudinal administration in critically ill patients
详细描述
An open label, monocenter pharmacokinetic study will be carried out in critically ill patients, admitted at the University Hospitals Leuven, receiving multiple dose treatment with fluconazole.
The exposure to fluconazole in the ICU cohort over multiple days of treatment will be documented. Moreover, variability and the correlating covariates that can influence the fluconazole concentration, will be determined.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •> 18 years
- •Treatment with fluconazole
- •Admitted to an ICU ward
排除标准
- •< 18 years
- •DNR 2 or 3
结局指标
主要结局
Exposure to fluconazole (trough levels)
时间窗: June 2020
Determine if the Cmin target levels are attained.
次要结局
- Variability in fluconazole trough levels(June 2020)
- Influencing covariates(June 2020)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
1 期
A Study in Healthy Men to Test How Fluconazole Influences the Amount of BI 425809 in the BloodHealthyNCT05076409Boehringer Ingelheim15
已完成
1 期
Pharmacokinetics (PK) Study of a Fluconazole Loading Dose in Infants and ToddlersCandidiasisNCT00797420Daniel Benjamin13
已完成
1 期
A Study to Evaluate the Effect of Fluconazole and Itraconazole on Erdafitinib Pharmacokinetics in Healthy Adult ParticipantsHealthyNCT03135106Janssen Research & Development, LLC54
已完成
1 期
Effect of Fluconazole on the Pharmacokinetics of Pyrotinib in Healthy SubjectsHealthy SubjectsNCT04850651Jiangsu HengRui Medicine Co., Ltd.18
已完成
1 期
Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy SubjectsRSV InfectionNCT04871724Enanta Pharmaceuticals, Inc24