Biperiden pharmacological-MRI as a tool to assess the function of the central cholinergic system: a validation study

Completed

• Conditions: centrale cholinerge systeem; 10009841; NA

• Registration Number: NL-OMON43422
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 15

Inclusion Criteria

- For men: age 40 years and older. For women: 50 years and older
- Mentally competent to sign informed consent.

Exclusion Criteria

- Use of anticholinergic medication
- Contraindications for MRI (e.g. metal implants, pacemaker etc.)
- Severe neurological, endocrine or psychiatric disorders (e.g., depression, bipolar illness)
- Pregnancy
- Current use of recreational drugs; participants must have abstained from using recreational drugs such as cannabis for at least 4 weeks prior to participation.
- Contraindications for biperiden
- Contraindications for potassium iodide

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- M1 receptor availability in the ACC, striatum and hippocampus.<br /><br>- Change in free choline concentrations in the ACC and striatum</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>