cAMP Signaling and Muscle Adaptations

Not Applicable

• Conditions: Muscle Hypertrophy in Healthy Young Men
• Interventions: Other: No training; Other: Endurance training; Drug: Clenbuterol; Other: Resistance Training; Drug: Placebo; Drug: Terbutaline

• Registration Number: NCT02557581
• Lead Sponsor: University of Copenhagen

Brief Summary

The role of cAMP signaling mediated by beta2-adrenergic stimulation with agonists has been well-studied in skeletal muscles of animals. Studies in humans are scant and the scope of the present study is thus to investigate the role of cAMP signaling by beta2-adrenergic stimulation for muscle adaptations in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-07
• Study First Submitted: 2015-09-13
• Study First Submitted QC: 2015-09-22
• Study First Posted: 2015-09-23
• Primary Completion: 2017-06-30
• Status Verified: 2017-10
• Study Completion: 2017-10
• Last Update Submitted: 2017-10-25
• Last Update Posted: 2017-10-26

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 72

Inclusion Criteria

• healthy young men
• 18-35 years of age
• Informed consent
• Active 2-5 hours of training pr. week
• Maximal oxygen uptake (ml/min/kg) of 40-60
• Lean body mass of 55-65 kg / Lean mass index 14-22 kg/m2

Exclusion Criteria

• Smoker
• Allergy towards study drugs
• Chronic disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Terbutaline	Endurance training	Beta2-adrenergic stimulation with terbutaline
Terbutaline	Resistance Training	Beta2-adrenergic stimulation with terbutaline
Placebo	No training	Placebo
Placebo	Endurance training	Placebo
Placebo	Resistance Training	Placebo
Placebo	Placebo	Placebo
Clenbuterol	No training	Beta2-adrenergic stimulation with clenbuterol
Terbutaline	No training	Beta2-adrenergic stimulation with terbutaline
Terbutaline	Terbutaline	Beta2-adrenergic stimulation with terbutaline
Clenbuterol	Clenbuterol	Beta2-adrenergic stimulation with clenbuterol

Primary Outcome Measures

Name	Time	Method
Muscle hypertrophy (lean body mass in Kilograms)	2 days	Lean body mass (kg) will be measured at two different days by Dual X-ray absorbance (DXA)

Secondary Outcome Measures

Name	Time	Method
Energy turnover (ml/min or mmol/kg dry weight muscle)	1 day	Pulmonary gas exchange and lactate and glycogen will be measured in muscle biopsies obtained before and after intense exercise

Trial Locations

Locations (2)

Department of Nutrition, Exercise and Sports; 🇩🇰 Copenhagen, Denmark

Bispebjerg University Hospital; 🇩🇰 Copenhagen, Denmark