ong Term Impact of Chronic Q-fever or the Q-fever Fatigue Syndrome on Psychosocial Functioning and Work Status
- Conditions
- 1001842410004018Q fever fatigue syndrome (QFS) / chronic Q fever
- Registration Number
- NL-OMON42447
- Lead Sponsor
- niversitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 1000
Patients meeting the criteria of proven or probable chronic Q-fever according to the Dutch consensus guidelines on chronic Q-fever diagnostics and diagnosed after the Q-fever outbreak of 2007 are eligible for this study.;Patients with QFS are diagnosed according to the following criteria:
- Fatigue persisting longer than 6 months
- Laboratory-confirmed acute Q-fever
- no recent (<3 months ago) chronic Q-fever diagnosis (as described in the previous paragraph)
- no somatic or psychiatric co-morbidity, which could explain the symptoms
- fatigue causes significant limitations in daily life (work or home)
- fatigue symptoms were not present prior to the acute Q-fever infection or since then clearly increased in severity (so-called *knikmoment* or turning point);We will only include the partner of the patients, if the patient has indicated to be married, have a registered partnership or is living together with their partner. ;Patients with diabetes will be included if they have received their diagnosis around 5 to 10 years ago, and are comparable with the Q-fever group in age and gender.
Patients diagnosed with a possible chronic Q-fever are not eligible for participation in this study, as the majority of these patients ultimately appear not to have chronic Q-fever.;Patients with diabetes and persons in the reference group from the general population will be excluded if they have had a positive Q-fever diagnosis at any time in their life, including no diagnosis of chronic Q-fever or QFS.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameters will be the summary scores on work status and<br /><br>psychosocial functioning, measured with several questionnaires (e.g. the<br /><br>Nijmegen Clinical Screening Instrument, SF-36, Work Ability Index and the<br /><br>Maudsley Marital Questionnaire). </p><br>
- Secondary Outcome Measures
Name Time Method <p>Various validated questionnaires will be used to measure possible mediating<br /><br>factors, baseline values and/or confounders, such as: fatgue, cognitive<br /><br>functioning, illness perception, age, gender, education level, health and<br /><br>disease related parameters and co-morbidity. </p><br>