Inorganic Pyrophosphate in Peripheral Arterial Disease

• Conditions: intermitent claudication; Peripheral arterial disease; 10003216

• Registration Number: NL-OMON48386
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

1. Age 18 and older.
2. One of four grades of Fontaine classification:
a. Fontaine I: Asymptomatic, incomplete blood vessel obstruction.
b. Fontaine II: Mild claudication pain in limb.
c. Fontaine III: Rest pain, mostly in the feet.
d. Fontaine IV: Necrosis and/or gangrene of the limb.

Exclusion Criteria

1. Subjects who are unable or unwilling to sign an informed consent.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in plasma PPi levels in patients with PAD with different Fontaine<br /><br>stages and healthy controls.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Differences in other plasma calcification inhibitors in patients with PAD with<br /><br>different Fontaine stages and healthy controls.</p><br>