Peak Cough Flow and Cough Clearance in Patients With Muscular Dystrophy

Completed

• Conditions: Duchenne Muscular Dystrophy

• Registration Number: NCT02034305
• Lead Sponsor: University of Pittsburgh

Brief Summary

This study is to determine whether physiologic measures (peak cough flow, measures of respiratory muscle strength including MIP, MEP ,SNIP, and spirometry) can predict spontaneous cough clearance (as measured by a nuclear medicine study) in children with neuromuscular disease. It will also determine whether airway clearance is augmented by high frequency chest wall oscillation.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Study First Submitted: 2014-01-09
• Study First Submitted QC: 2014-01-10
• Study First Posted: 2014-01-13
• Status Verified: 2021-01
• Primary Completion: 2021-01-01
• Study Completion: 2021-01-01
• Last Update Submitted: 2024-02-02
• Last Update Posted: 2024-02-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 7

Inclusion Criteria

• Age 6-21; able to cooperate with study procedures
• Duchenne Muscular Dystrophy OR Becker Muscular Dystrophy

Exclusion Criteria

• Need for mechanical ventilation during the day
• Recent (within 2 weeks) lower respiratory tract infection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Spontaneous cough clearance	Assessed at multiple time points over 30 minutes

Trial Locations

Locations (1)

Children's Hospital of Pittsburgh; 🇺🇸 Pittsburgh, Pennsylvania, United States