A clinical trial to study the effect of addition of drugs Dexmedetomidine and Dexamethasone to regional nerve block of upper extremity surgeries

Not Applicable

• Conditions: Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue

• Registration Number: CTRI/2021/08/035448
• Lead Sponsor: Jubilee Mission Medical College and Research Institute

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Age from 18 years to 65 years

2. American Society of Anaesthesiologists (ASA) physical status class I and II

3. Patients scheduled for upper limb surgeries at the level of mid shaft of humerus and below

Exclusion Criteria

1. Patient refusal for study participation

2. Local infection at injection site

3. Presence of any coagulopathies, bleeding disorders or patients on anticoagulants

4. Presence of neurological deficits, peripheral neuropathies, myopathies or chronic pain in the operating limb

5. Patients with known allergy to local anaesthetics or to any of the study drugs to be used

6. Patients with baseline bradycardia or on beta blockers/alpha agonists

7. Hemodynamically compromised patients

8. Alcoholic/psychiatric/uncooperative patients

9. Pregnant and breast-feeding mothers

10.Patients with diabetes, hepatic/renal or cardiopulmonary disorders

11.Morbid obesity

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Onset and duration of sensory and motor blockadeTimepoint: Onset of sensory and motor blockade will be assessed every 3 minutes after the completion of injection upto 60 minutes. <br/ ><br> <br/ ><br>Duration of sensory and motor blockade will be assessed in the first 24 hours after block.

Secondary Outcome Measures

Name	Time	Method
1. Duration of analgesia <br/ ><br>2. Hemodynamic parameters during surgeryTimepoint: Duration of analgesia is the time from commencement of block to patientâ??s first request for rescue analgesic in the first 24 hours. <br/ ><br> <br/ ><br>Heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, oxygen saturation and respiratory rate will be recorded for first 6 hours.