Periodontal regeneration in infrabony defects

Not yet recruiting

• Conditions: Infrabony defect; Periodontal disease, unspecified,

• Registration Number: CTRI/2024/04/065200
• Lead Sponsor: Sharad Pawar Dental College

Brief Summary

**Introduction:** Periodontitis is a chronic, multifactorial, inflammatory disease that leads to gradual loss of bone and periodontal attachment. Thus, periodontal surgery is required according to severity of diseases. The goal of periodontal reconstructive surgery is to regenerate soft and hard tissues destroyed during periodontal disease.

**Aim:** To compare the effectiveness of Bioresorbable Collagen Membrane in combination with Deproteinized Bovine Bone Matrix xenograft and Advanced Plasma rich fibrin(A-PRF) membrane in combination with Deproteinized Bovine Bone Matrix xenograft in the treatment of human infrabony defects.

**Methods and Materials:** This randomised controlled trial will be carried out at the periodontics outpatient department. We will choose 24 patients with moderate to advanced chronic periodontitis who are also systemically healthy. Infrabony defects will be treated by open flap debridement using bovine-derived xenograft and bioresorbable collagen membrane (group A) and open flap debridement using bovine-derived xenograft and A-PRF after the completion of first therapy (group B). At baseline and six months after undergoing periodontal surgery, probing pocket depth, clinical attachment level, radiographic bone fill, gingival recession, oral hygiene status, and gingival health were measured.

**Expected Results:** Bioresorbable Collagen Membrane and Advanced-Platelet Rich Fibrin Membrane in Combination with Deproteinized Bovine Bone Matrix Xenograft will lead to decrease in PPD, increase in CAL and better radiographic bone fill in infrabony defects.

**Conclusion:** It is suggested that Bioresorbable Collagen Membrane in combination with Deproteinized Bovine Bone Matrix xenograft will show better results as compared to Advanced Platelet Rich Fibrin Membrane with Deproteinized Bovine Bone Matrix Xenograft.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2024-04-03
• Study Start: 2024-05-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• 1)“Presence of at least 1 or 2 radiographically detectable interproximal infrabony osseous defect with probing pocket depth ≥ 5 mm and clinical attachment loss ≥ 5 mm following initial therapy.
• 2)Depth of intraosseous component of the defect ≥ 3 mm by clinical and radiographic means, which will be confirmed on intra-surgical measurement.
• 3)A radiographic base of the defect at least 3 mm coronal to the apex of the tooth.
• 4. Presence of at least 3 mm width of keratinized gingiva around test teeth to allow complete soft tissue coverage of the defect.â€.

Exclusion Criteria

• 1)“Evidence of localized aggressive periodontitis.
• 2)Patients with unacceptable oral hygiene (Plaque Index >1) 3)Smokers (recent history of smoking more than 10 cigarettes /day) or who used any of tobacco products.
• 4)Study tooth with inadequate endodontic / restorative treatments.
• 5)Study tooth with mobility exceeding grade II and exhibiting a class III or class IV furcation defect.
• 6)History of periodontal surgical therapy of the selected quadrant.
• 7)Pregnant females or lactating mothers.â€.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Radiographic bone fill	At six months

Secondary Outcome Measures

Name	Time	Method
Plaque index,Papillary bleeding index,Periodontal pocket depth reduction,Clinical attachment level gain	At six months

Trial Locations

Locations (1)

Sharad Pawar Dental College, Sawangi, Wardha; 🇮🇳 Wardha, MAHARASHTRA, India

Sharad Pawar Dental College, Sawangi, Wardha

🇮🇳Wardha, MAHARASHTRA, India

Shweta Bhagat

Principal investigator

08319131268

shweta.bnbde@gmail.com