Effect of high dose vitamin D on IL-ß blood level in patients with moderate stroke

Phase 3

Conditions: cerebrovascular accident.

Registration Number: IRCT20200213046484N2

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: 42

Inclusion Criteria

Patients with moderate stroke (NIHSS 5-15)
Age between 18 to 65 years
Vitamin D levels less than 30 ng/ml

Exclusion Criteria

Hypercalcemia (Ca > 10.5 mg/dl)
Patients treated with corticosteroids, NSAIDs, statins
History of diseases such as cancer, autoimmune disorders, liver diseases
Pregnancy and breastfeeding
History of allergy to vitamin D
Poor chance of survival

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IL1-ß. Timepoint: Before intervention and 3rd day after intervention. Method of measurement: Elisa kit.;Neutrophil to Lymphocyte Ratio (NLR). Timepoint: First to 7th day of the study on daily routine. Method of measurement: Calculating the ratio of Neutrophils to Lymphocytes using CBC test.;Platelet to Lymphocyte Ratio (PLR). Timepoint: First to 7th day of the study on daily routine. Method of measurement: Calculating the ratio of Platelet to Lymphocytes using CBC test.;National Institutes of Health Stroke Scale (NIHSS). Timepoint: First to 7th day of the study on daily routine. Method of measurement: Patient medical file.;Barthel Score. Timepoint: Three months after discharge. Method of measurement: Questionnaire.

Secondary Outcome Measures

Name	Time	Method
enght of ICU stay. Timepoint: Daily. Method of measurement: Patient file.;Duraton of Mechanical Ventilation. Timepoint: Daily. Method of measurement: Patient file.;28-day mortality. Timepoint: 28th day of hospitalization. Method of measurement: Patient file.