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Clinical Trials/NCT03056781
NCT03056781
Completed
Not Applicable

Emotional Response in Psychiatric and Control Participants

University of California, Irvine1 site in 1 country46 target enrollmentFebruary 15, 2017

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Schizophrenia
Sponsor
University of California, Irvine
Enrollment
46
Locations
1
Primary Endpoint
Social Anhedonia Scale
Status
Completed
Last Updated
7 years ago

Overview

Brief Summary

The purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health concerns. A large body of literature suggests that people with mental illnesses have emotional abnormalities compared to healthy individuals, but a number of these abnormalities are not well understood. For example, often people with schizophrenia report on questionnaires that they experience fewer pleasant emotions when talking with other people, but some evidence suggests these individuals report a similar amount of pleasant emotion when they are actually engaged in a pleasant activity. Thus, it is unclear the extent to which reports of emotional abnormalities extend to a more real-world setting. In the tasks in the current proposal, participants will engage in a series of tasks designed to assess their emotional functioning. These tasks involve viewing emotional stimuli on the computer, engaging in social interactions, and consuming small amounts of food. In all tasks, participants will make ratings of their experiences of pleasure (and displeasure). We will then compare the experiences of patient groups to those of healthy individuals to test how emotional ratings might differ across these tasks.

Registry
clinicaltrials.gov
Start Date
February 15, 2017
End Date
August 1, 2018
Last Updated
7 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Elizabeth A. Martin

Assistant Professor

University of California, Irvine

Eligibility Criteria

Inclusion Criteria

  • For control participants, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have not been clinically diagnosed with a psychiatric disorder.
  • For psychiatric patients, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have been clinically diagnosed with schizophrenia, schizoaffective disorder, or depression with no recent hospitalization or changes in your psychiatric medications.

Exclusion Criteria

  • For control participants, you are not eligible to participate in the study if you have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months. You are not eligible to participate if you have a current or past history of a major medical illness, significant tremors, a history of a head injury or prolonged unconsciousness.
  • For psychiatric patients, you are not eligible to participate in the study if you have had major changes to your psychotropic medications within the last two months, have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months, a current or past history of a major medical illness, significant tremors, or a history of a head injury or prolonged unconsciousness.

Outcomes

Primary Outcomes

Social Anhedonia Scale

Time Frame: 1 day

measures social anhedonia

Physical Anhedonia Scale

Time Frame: 1 day

measures physical anhedonia

EEG activity

Time Frame: 1 day

physiological parameter

Verbal behavioral rating

Time Frame: 1 day

how many words are spoken throughout the task

Non-verbal behavioral rating

Time Frame: 1 day

how many gestures are made throughout the task

International Personality Item Pool questionnaires

Time Frame: 1 day

measure of personality

Secondary Outcomes

  • Following Affective States test(1 day)
  • AMNART(1 day)
  • MMSE(1 day)

Study Sites (1)

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