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临床试验/NCT03056781
NCT03056781已完成不适用

Emotional Response in Psychiatric and Control Participants

University of California, Irvine2 个研究点 分布在 1 个国家目标入组 46 人开始时间: 2017年2月15日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
入组人数
46
试验地点
2
主要终点
Social Anhedonia Scale

研究概览

简要总结

The purpose of this research is to understand how the emotions of people with different mental health concerns (e.g., people with schizophrenia, people with major depressive disorder) differ from individuals without mental health concerns. A large body of literature suggests that people with mental illnesses have emotional abnormalities compared to healthy individuals, but a number of these abnormalities are not well understood. For example, often people with schizophrenia report on questionnaires that they experience fewer pleasant emotions when talking with other people, but some evidence suggests these individuals report a similar amount of pleasant emotion when they are actually engaged in a pleasant activity. Thus, it is unclear the extent to which reports of emotional abnormalities extend to a more real-world setting. In the tasks in the current proposal, participants will engage in a series of tasks designed to assess their emotional functioning. These tasks involve viewing emotional stimuli on the computer, engaging in social interactions, and consuming small amounts of food. In all tasks, participants will make ratings of their experiences of pleasure (and displeasure). We will then compare the experiences of patient groups to those of healthy individuals to test how emotional ratings might differ across these tasks.

研究设计

研究类型
Interventional
分配方式
Non Randomized
干预模型
Parallel
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • For control participants, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have not been clinically diagnosed with a psychiatric disorder.
  • For psychiatric patients, you are eligible to participate in this study if you are between 18 and 65 years of age, you are fluent in English, and you have been clinically diagnosed with schizophrenia, schizoaffective disorder, or depression with no recent hospitalization or changes in your psychiatric medications.

排除标准

  • For control participants, you are not eligible to participate in the study if you have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months. You are not eligible to participate if you have a current or past history of a major medical illness, significant tremors, a history of a head injury or prolonged unconsciousness.
  • For psychiatric patients, you are not eligible to participate in the study if you have had major changes to your psychotropic medications within the last two months, have a history of stroke or a current history of substance or alcohol dependence. You are also not eligible to participate in this study if you have had a diagnosis of substance abuse in the past three months, a current or past history of a major medical illness, significant tremors, or a history of a head injury or prolonged unconsciousness.

研究组 & 干预措施

food consumption

Experimental

Participants will be offered food stuffs to eat/drink

干预措施: food consumption (Behavioral)

social interaction

Experimental

Participants will engage in a social interaction with another person

干预措施: social interaction (Behavioral)

结局指标

主要结局

Social Anhedonia Scale

时间窗: 1 day

measures social anhedonia

Physical Anhedonia Scale

时间窗: 1 day

measures physical anhedonia

EEG activity

时间窗: 1 day

physiological parameter

Verbal behavioral rating

时间窗: 1 day

how many words are spoken throughout the task

Non-verbal behavioral rating

时间窗: 1 day

how many gestures are made throughout the task

International Personality Item Pool questionnaires

时间窗: 1 day

measure of personality

次要结局

  • Following Affective States test(1 day)
  • AMNART(1 day)
  • MMSE(1 day)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Elizabeth A. Martin

Assistant Professor

University of California, Irvine

研究点 (2)

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