Lung Volume Recruitment for Lung Function and Cough Impairment in Multiple Sclerosis
Not Applicable
- Conditions
- Multiple Sclerosis
- Registration Number
- NCT01891071
- Lead Sponsor
- Ottawa Hospital Research Institute
- Brief Summary
Multiple sclerosis is a neurological disease that can affect lung function and cough efficacy. This pilot study will examine whether the lung volume recruitment technique can slow down the decline in lung function and cough.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 35
Inclusion Criteria
- History of multiple sclerosis, diagnosed by a neurologist in accordance with the 2010 McDonald criteria
Exclusion Criteria
- Concomitant parenchymal pulmonary disease or pleural disease
- Symptomatic cardiomyopathy
- Unable to perform pulmonary function testing or lung volume recruitment, due to comprehension or cooperation issues, physical inability such as bulbar or cerebellar dysfunction
- Contra-indication to pulmonary function testing or lung volume recruitment such as myocardial infarction, bleeding aortic aneurysm, intracranial hemorrhage within the previous month
- Known susceptibility to pneumothorax or pneumomediastinum
- Not competent to provide informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Rate of decline of FVC (forced vital capacity) up to 9 months
- Secondary Outcome Measures
Name Time Method Rate of decline of peak cough flow baseline, 2, 4, 6 and 9 months Change from baseline in FVC at 2, 4, 6 and 9 months baseline vs 2, 4, 6 and 9 months Change from baseline in peak cough flow at 2, 4, 6 and 9 months baseline vs 2, 4, 6 and 9 months
Trial Locations
- Locations (2)
The Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
Hôpital Charles-LeMoyne
🇨🇦Greenfield Park, Quebec, Canada
The Ottawa Hospital🇨🇦Ottawa, Ontario, Canada