Effects of Oxytocin on Hemodynamics in Patients Undergoing Laparoscopic Myomectomy

Not Applicable

• Conditions: Oxytocin; Hemodynamic Monitoring; Laparoscopic Surgery
• Interventions: Drug: Oxytocin

• Registration Number: NCT04109339
• Lead Sponsor: Yangzhou University

Brief Summary

This project will study the effect of oxytocin on hemodynamics in patients undergoing laparoscopic myomectomy, and how to prevent and manage such hemodynamic changes effectively.It provides a reference for the rational use of oxytocin in clinical practice, which can not only effectively contract the uterus and reduce bleeding, but also reduce the influence on hemodynamics.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-01
• Study First Submitted: 2019-08-15
• Status Verified: 2019-09
• Study First Submitted QC: 2019-09-26
• Last Update Submitted: 2019-09-26
• Study First Posted: 2019-09-30
• Last Update Posted: 2019-09-30
• Primary Completion: 2019-12-31
• Study Completion: 2020-10-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 80

Inclusion Criteria

• General anesthesia for gynecological laparoscopic surgery,ASA I~III

Exclusion Criteria

• Oxytocin use contraindications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group 3 with oxytocin 20 U IM + oxytocin 0 U IV	Oxytocin	-
group 2 with oxytocin 10 U IM + oxytocin 10 U IV	Oxytocin	-
group 4 with oxytocin 0 U IM + oxytocin 20 U IV	Oxytocin	-

Primary Outcome Measures

Name	Time	Method
Changes of volume management parameters after oxytocin use during laparoscopic hysteromyomectomia.	"before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".	CO (l/min) was measured by a Mostcare hemodynamic monitor.
Changes of traditional hemodynamic parameters after oxytocin use during laparoscopic hysteromyomectomia.	"before induction", "before incision", "before oxytocin intramuscular injection", and "20 sec, 40 sec, 60 sec, 80 sec, 100 sec, 120 sec, 140 sec, 160 sec,180 sec after oxytocin intramuscular injection".	HR (beats/min) was measured by a Mostcare hemodynamic monitor.

Trial Locations

Locations (1)

the Affiliated Hospital of Yangzhou University; 🇨🇳 Yangzhou, Jiangsu, China