Role of Uterotonics in Reducing Intraoperative Blood Loss in Patients With PASD Undergoing Cesarean Hysterectomy

Not Applicable

Recruiting

• Conditions: Placenta Accreta Spectrum
• Interventions: Drug: oxytocin; Other: placebo

• Registration Number: NCT06493968
• Lead Sponsor: Cairo University

Brief Summary

Objectives: To evaluate the effect of oxytocin in reducing intraoperative blood loss in patients with PAS disorders planned for cesarean hysterectomy.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-07
• Study Start: 2024-07-01
• Study First Submitted: 2024-07-02
• Study First Submitted QC: 2024-07-02
• Last Update Submitted: 2024-07-02
• Study First Posted: 2024-07-10
• Last Update Posted: 2024-07-10
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

• Pregnancy of singleton living fetus
• Previous one or more cesarean sections
• Gestational age: > 32 weeks
• The following ultrasound markers such as "loss of clear retroplacental translucency", "myometrial thinning", "abnormal lacunae", "irregular bladder wall", "utero-vesicalhypervascularity".
• Preoperative hemoglobin more than 10 gm/dl
• Cases with PAS that will undergoing CS Hysterectomy

Exclusion Criteria

• Maternal medical disorders e.g.: coagulation defects, cardiac diseases etc.....
• Any known or reported hypersensitivity to the used medication.
• All cases with spontaneous placental separation at laparotomy.
• All patients undergoing conservative management of PAS.
• All cases which necessitate emergency termination.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group (A)	oxytocin	Patients will be given uterotonics
Group (B)	placebo	Patients will not be given uterotonics

Primary Outcome Measures

Name	Time	Method
Intraoperative blood loss	during operation	amount of intraoperative blood loss in patients with PAS disorders undergoing cesarean hysterectomy

Secondary Outcome Measures

Name	Time	Method
operative time	during operation

Trial Locations

Locations (1)

Cairo University; 🇪🇬 Cairo, Egypt