The Impact of Dietary Nitrate Supplementation on Exercise-induced Cardiac Troponin T Release in Type 2 Diabetic Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Cardiac troponin T
研究概览
简要总结
Blood cardiac troponin T (cTnT) concentration is a widely used marker of acute cardiac injury. Previous research has shown that type 2 diabetic patients may experience large increments in cTnT levels over the subsequent hours following a single bout of moderate-intensity endurance-type exercise. This phenomenon is likely attributed to cardiac ischemia-reperfusion injury caused by reduced nitric oxide (NO) bioavailability. Recent evidence indicates that ingestion of dietary nitrates dramatically increases the bioavailability of NO, and as such, may be protective against cardiac ischemia-reperfusion injury.
The investigators hypothesize that dietary nitrate supplementation blunts the rise in cTnT levels following exercise in type 2 diabetic patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •exercise-induced cTnT release (>3ng/L)
排除标准
- •HbA1c <6.0% or >10.0%
- •morbid obesity (BMI>35 kg/m2)
- •incident cardiovascular events in the last year (heart attack, stroke
- •use medication which contain nitrates and/or having vasodilatory effects
结局指标
主要结局
Cardiac troponin T
时间窗: 9 hours, hourly time intervals
Cardiac troponin T levels will be assessed before exercise and over the 6-hour period following a single session of exercise.
次要结局
- Plasma nitrite(9 hours, hourly time intervals)
- Blood pressure(day)
- Plasma nitrate(9 hours, hourly time intervals)