Salivary cortisol response and VO2max during standardized excercise test in children with and without asthma

Withdrawn

• Conditions: adrenal response; physical condition; 10001353

• Registration Number: NL-OMON41096
• Lead Sponsor: Martini Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Group 1: Healthy children
boys age 8-12 years
prepuberal according to Tanner stage
BMI -1.1 to 1.1 SD
No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 2: Children with asthma
boys age 8-12 years
prepuberal according to Tanner stage
BMI -1.1 to 1.1 SD
stable asthma (no change in maintenance medication and no systemic steroids in previous 3 months)
Maintenance dose of inhaled corticosteroids < 500 microgram per day (fluticasone equivalent)
Normal pulmonary function (FEV1 > 90% of predicted value)
No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school);Group 3: children with newly diagnosed asthma
boys age 8-12 years
prepuberal according to Tanner stage
BMI -1.1 to 1.1 SD
No use of inhaled corticosteroids and no systemic steroids in previous 6 months
Normal pulmonary function (FEV1 > 90% of predicted value)
No limitations to perform exercise test (participates in community sports and/or physcial exercise lessons at school)

Exclusion Criteria

No informed consent
If exercise test are contraindicated due to physical condition or comorbidity as judged by treating physisian
If the child does not cooperate or does not want to continue the tests
Use of medication which may potentially affect steroid metabolism

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Salivary cortisol respons and VO2max of the children with asthma compared to<br /><br>the healthy children<br /><br>. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlation between salivary cortisol respons and VO2max</p><br>