S0812 High Dose Cholecalciferol in Premenopausal Women at High-Risk for Breast Cancer
- Conditions
- brca2 Mutation CarrierBreast Cancerbrca1 Mutation Carrier
- Interventions
- Dietary Supplement: cholecalciferolOther: placebo
- Registration Number
- NCT01097278
- Lead Sponsor
- SWOG Cancer Research Network
- Brief Summary
RATIONALE: Cholecalciferol may prevent breast cancer in premenopausal women.
PURPOSE: This randomized phase II trial is studying how well cholecalciferol works in preventing breast cancer in premenopausal women.
- Detailed Description
OBJECTIVES:
* To assess whether mammographic density is reduced in premenopausal women at high risk of breast cancer taking high-dose vitamin D3 (oral cholecalciferol 20,000 IU weekly) vs placebo for 1 year.
* To assess whether proliferation as measured by Ki-67 staining of breast epithelial cells is reduced in women receiving these treatments.
* To explore the difference in the expression of other biomarkers (including cleaved caspase-3 \[apoptosis marker\], ER, vitamin D receptor \[VDR\], and 1α-hydroxylase) in breast tissue obtained from these women.
* To assess whether parathyroid hormone, IGF-1, IGFBP-3, 25(OH)D, and 1,25(OH)D serum levels are altered in these women at baseline and at 6 and 12 months.
* To explore whether a change in mammographic density correlates with polymorphisms in the VDR gene.
* To assess other sources of vitamin D (sunlight exposure, diet) in these women using a validated questionnaire administered at baseline and at 12 and 24 months.
* To collect and bank serum, plasma, and breast tissue from these women before and after a 1-year intervention with vitamin D for future biomarker analysis.
* To assess the toxicity of high-dose cholecalciferol compared to placebo in this setting.
OUTLINE: This is a multicenter study. Participants are stratified according to baseline serum 25(OH)D level (\< 20 ng/mL vs 20-32 ng/mL or \< 50 nmol/L vs 50-80 nmol/L), baseline mammographic density (11-50% vs \> 50%), and designated biopsy site (yes vs no). Participants are randomized to 1 of 2 treatment arms.
* Arm I: Participants receive oral cholecalciferol once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
* Arm II: Participants receive oral placebo once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
Blood samples are collected at baseline and periodically thereafter for biomarkers and 25(OH)D level. Participants undergo a mammogram at baseline and at 12 months. Participants may also undergo random core-needle breast biopsy at baseline and at 12 months.
Participants complete a questionnaire at baseline and at 12 and 24 months.
After completion of study therapy, participants are followed up at 1 and 12 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 208
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Arm I cholecalciferol Participants receive oral cholecalciferol once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity. Arm II placebo Participants receive oral placebo once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity. Arm II cholecalciferol Participants receive oral placebo once weekly and oral vitamin D once daily. Treatment repeats for 12 months in the absence of evidence of cancer or unacceptable toxicity.
- Primary Outcome Measures
Name Time Method Change in mammographic density at 12 months compared to baseline 12 months
- Secondary Outcome Measures
Name Time Method Ki-67 as assessed in tissue obtained in breast biopsies at baseline and at 12 months 12 months
Trial Locations
- Locations (360)
Saint Mary Corwin Medical Center
🇺🇸Pueblo, Colorado, United States
Memorial Hospital of South Bend
🇺🇸South Bend, Indiana, United States
Great Falls Clinic
🇺🇸Great Falls, Montana, United States
AnMed Health Cancer Center
🇺🇸Anderson, South Carolina, United States
Longmont United Hospital
🇺🇸Longmont, Colorado, United States
Michiana Hematology Oncology PC-Elkhart
🇺🇸Elkhart, Indiana, United States
Comprehensive Cancer Care and Research Institute of Colorado LLC
🇺🇸Englewood, Colorado, United States
Rocky Mountain Cancer Centers-Longmont
🇺🇸Longmont, Colorado, United States
Rocky Mountain Cancer Centers - Pueblo
🇺🇸Pueblo, Colorado, United States
Cancer Center of Kansas-Independence
🇺🇸Independence, Kansas, United States
North Memorial Medical Health Center
🇺🇸Robbinsdale, Minnesota, United States
United Hospital
🇺🇸Saint Paul, Minnesota, United States
Montana Cancer Specialists
🇺🇸Missoula, Montana, United States
Nebraska Cancer Research Center
🇺🇸Lincoln, Nebraska, United States
Minnesota Oncology and Hematology PA-Woodbury
🇺🇸Woodbury, Minnesota, United States
Central Care Cancer Center-Carrie J Babb Cancer Center
🇺🇸Bolivar, Missouri, United States
Kalispell Regional Medical Center
🇺🇸Kalispell, Montana, United States
AnMed Health Hospital
🇺🇸Anderson, South Carolina, United States
Hawaii Cancer Care Inc-POB II
🇺🇸Honolulu, Hawaii, United States
Queen's Medical Center
🇺🇸Honolulu, Hawaii, United States
Straub Clinic and Hospital
🇺🇸Honolulu, Hawaii, United States
Hawaii Cancer Care Inc-Liliha
🇺🇸Honolulu, Hawaii, United States
Hawaii Oncology Inc-Kuakini
🇺🇸Honolulu, Hawaii, United States
Baptist Health Lexington
🇺🇸Lexington, Kentucky, United States
Providence Alaska Medical Center
🇺🇸Anchorage, Alaska, United States
UC Irvine Health Cancer Center-Newport
🇺🇸Costa Mesa, California, United States
Contra Costa Regional Medical Center
🇺🇸Martinez, California, United States
Alta Bates Summit Medical Center - Summit Campus
🇺🇸Oakland, California, United States
Hematology and Oncology Associates-Oakland
🇺🇸Oakland, California, United States
UC Irvine Health/Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
East Bay Medical Oncology Hematology Medical Associates Inc-Pleasant Hill
🇺🇸Pleasant Hill, California, United States
Valley Medical Oncology Consultants
🇺🇸Pleasanton, California, United States
Presbyterian Intercommunity Hospital
🇺🇸Whittier, California, United States
Mountain Blue Cancer Care Center
🇺🇸Golden, Colorado, United States
The Methodist Hospital System
🇺🇸Houston, Texas, United States
Rocky Mountain Cancer Centers-Lakewood
🇺🇸Lakewood, Colorado, United States
Rocky Mountain Cancer Centers-Greenwood Village
🇺🇸Greenwood Village, Colorado, United States
Parker Adventist Hospital
🇺🇸Parker, Colorado, United States
SCL Health Lutheran Medical Center
🇺🇸Wheat Ridge, Colorado, United States
Oncare Hawaii Inc-Pali Momi
🇺🇸'Aiea, Hawaii, United States
Dekalb Medical Center
🇺🇸Decatur, Georgia, United States
Saint Luke's Mountain States Tumor Institute
🇺🇸Boise, Idaho, United States
Saint Anthony's Health
🇺🇸Alton, Illinois, United States
Saint Joseph Medical Center
🇺🇸Bloomington, Illinois, United States
Illinois CancerCare-Canton
🇺🇸Canton, Illinois, United States
Illinois CancerCare-Bloomington
🇺🇸Bloomington, Illinois, United States
Illinois CancerCare-Carthage
🇺🇸Carthage, Illinois, United States
Memorial Hospital of Carbondale
🇺🇸Carbondale, Illinois, United States
Centralia Oncology Clinic
🇺🇸Centralia, Illinois, United States
Decatur Memorial Hospital
🇺🇸Decatur, Illinois, United States
Cancer Care Center of Decatur
🇺🇸Decatur, Illinois, United States
Illinois CancerCare-Galesburg Cottage Plaza Office
🇺🇸Galesburg, Illinois, United States
Illinois CancerCare-Galesburg
🇺🇸Galesburg, Illinois, United States
Illinois CancerCare-Kewanee Clinic
🇺🇸Kewanee, Illinois, United States
Good Samaritan Regional Health Center
🇺🇸Mount Vernon, Illinois, United States
Community Cancer Center Foundation
🇺🇸Normal, Illinois, United States
Illinois CancerCare-Ottawa Clinic
🇺🇸Ottawa, Illinois, United States
Proctor Hospital
🇺🇸Peoria, Illinois, United States
OSF Saint Francis Medical Center
🇺🇸Peoria, Illinois, United States
Illinois CancerCare-Peru
🇺🇸Peru, Illinois, United States
Community Howard Regional Health
🇺🇸Kokomo, Indiana, United States
Saint Joseph Regional Medical Center-Mishawaka
🇺🇸Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-South Bend
🇺🇸South Bend, Indiana, United States
South Bend Clinic
🇺🇸South Bend, Indiana, United States
Mercy Medical Center-Sioux City
🇺🇸Sioux City, Iowa, United States
Saint Luke's Regional Medical Center
🇺🇸Sioux City, Iowa, United States
Providence Medical Center
🇺🇸Kansas City, Kansas, United States
Cancer Center of Kansas - Salina
🇺🇸Salina, Kansas, United States
Baptist Health Corbin
🇺🇸Corbin, Kentucky, United States
Lahey Hospital and Medical Center
🇺🇸Burlington, Massachusetts, United States
Beaumont Hospital-Dearborn
🇺🇸Dearborn, Michigan, United States
Botsford General Hospital
🇺🇸Farmington, Michigan, United States
Sparrow Hospital
🇺🇸Lansing, Michigan, United States
Saint Joseph Mercy Port Huron
🇺🇸Port Huron, Michigan, United States
William Beaumont Hospital-Royal Oak
🇺🇸Royal Oak, Michigan, United States
Marie Yeager Cancer Center
🇺🇸Saint Joseph, Michigan, United States
William Beaumont Hospital - Troy
🇺🇸Troy, Michigan, United States
Fairview Ridges Hospital
🇺🇸Burnsville, Minnesota, United States
Mercy Hospital
🇺🇸Coon Rapids, Minnesota, United States
Ridgeview Medical Center
🇺🇸Waconia, Minnesota, United States
Saint Francis Medical Center
🇺🇸Cape Girardeau, Missouri, United States
Liberty Radiation Oncology Center
🇺🇸Liberty, Missouri, United States
Saint Joseph Oncology Inc
🇺🇸Saint Joseph, Missouri, United States
Saint Louis Cancer and Breast Institute-South City
🇺🇸Saint Louis, Missouri, United States
Mercy Hospital Saint Louis
🇺🇸Saint Louis, Missouri, United States
Cancer Research for the Ozarks NCORP
🇺🇸Springfield, Missouri, United States
Saint Louis-Cape Girardeau CCOP
🇺🇸Saint Louis, Missouri, United States
CoxHealth South Hospital
🇺🇸Springfield, Missouri, United States
Montana Cancer Consortium NCORP
🇺🇸Billings, Montana, United States
Frontier Cancer Center and Blood Institute-Billings
🇺🇸Billings, Montana, United States
Glacier Oncology PLLC
🇺🇸Kalispell, Montana, United States
Hematology Oncology Associates of Central New York-East Syracuse
🇺🇸East Syracuse, New York, United States
Hematology Oncology Associates of Central New York-Auburn
🇺🇸Auburn, New York, United States
Columbia University/Herbert Irving Cancer Center
🇺🇸New York, New York, United States
Winthrop University Hospital
🇺🇸Mineola, New York, United States
Hematology Oncology Associates of Central New York-Rome
🇺🇸Rome, New York, United States
State University of New York Upstate Medical University
🇺🇸Syracuse, New York, United States
Hematology Oncology Associates of Central New York-Onondaga Hill
🇺🇸Syracuse, New York, United States
Cone Health Cancer Center
🇺🇸Greensboro, North Carolina, United States
Margaret R Pardee Memorial Hospital
🇺🇸Hendersonville, North Carolina, United States
Southern Oncology Specialists-Charlotte
🇺🇸Charlotte, North Carolina, United States
Hendersonville Hematology and Oncology at Pardee
🇺🇸Hendersonville, North Carolina, United States
Novant Health Cancer Specialists-Matthews
🇺🇸Matthews, North Carolina, United States
Southern Oncology Specialists-Huntersville
🇺🇸Huntersville, North Carolina, United States
Adena Regional Medical Center
🇺🇸Chillicothe, Ohio, United States
Annie Penn Memorial Hospital
🇺🇸Reidsville, North Carolina, United States
Columbus Oncology and Hematology Associates Inc
🇺🇸Columbus, Ohio, United States
Trinity Cancer Care Center
🇺🇸Minot, North Dakota, United States
The Mark H Zangmeister Center
🇺🇸Columbus, Ohio, United States
Mount Carmel Health Center West
🇺🇸Columbus, Ohio, United States
Delaware Radiation Oncology
🇺🇸Delaware, Ohio, United States
Grady Memorial Hospital
🇺🇸Delaware, Ohio, United States
Doctors Hospital
🇺🇸Columbus, Ohio, United States
Fairfield Medical Center
🇺🇸Lancaster, Ohio, United States
Marietta Memorial Hospital
🇺🇸Marietta, Ohio, United States
Newark Radiation Oncology
🇺🇸Newark, Ohio, United States
Knox Community Hospital
🇺🇸Mount Vernon, Ohio, United States
Licking Memorial Hospital
🇺🇸Newark, Ohio, United States
Springfield Regional Medical Center
🇺🇸Springfield, Ohio, United States
Saint Ann's Hospital
🇺🇸Westerville, Ohio, United States
Genesis Healthcare System Cancer Care Center
🇺🇸Zanesville, Ohio, United States
Providence Newberg Medical Center
🇺🇸Newberg, Oregon, United States
Legacy Meridian Park Hospital
🇺🇸Tualatin, Oregon, United States
Phoenixville Hospital
🇺🇸Phoenixville, Pennsylvania, United States
Greenville Health System Cancer Institute-Eastside
🇺🇸Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Spartanburg
🇺🇸Spartanburg, South Carolina, United States
Spartanburg Medical Center
🇺🇸Spartanburg, South Carolina, United States
Texas Tech University Health Science Center-Amarillo
🇺🇸Amarillo, Texas, United States
Pacific Medical Center-First Hill
🇺🇸Seattle, Washington, United States
Princeton Community Hospital
🇺🇸Princeton, West Virginia, United States
Rocky Mountain Oncology
🇺🇸Casper, Wyoming, United States
Greenville Health System Cancer Institute-Andrews
🇺🇸Greenville, South Carolina, United States
Saint Mary's of Michigan
🇺🇸Saginaw, Michigan, United States
Lakeland Hospital
🇺🇸Saint Joseph, Michigan, United States
Greenville Memorial Hospital
🇺🇸Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Greer
🇺🇸Greer, South Carolina, United States
Singing River Hospital
🇺🇸Pascagoula, Mississippi, United States
Billings Clinic Cancer Center
🇺🇸Billings, Montana, United States
Gibbs Cancer Center-Pelham
🇺🇸Greer, South Carolina, United States
Carolina Blood and Cancer Care Associates PA-Lancaster
🇺🇸Lancaster, South Carolina, United States
Bozeman Deaconess Hospital
🇺🇸Bozeman, Montana, United States
Saint James Community Hospital and Cancer Treatment Center
🇺🇸Butte, Montana, United States
Benefis Healthcare- Sletten Cancer Institute
🇺🇸Great Falls, Montana, United States
Saint Peter's Community Hospital
🇺🇸Helena, Montana, United States
University of Arizona Cancer Center-North Campus
🇺🇸Tucson, Arizona, United States
Greenville Health System Cancer Institute-Seneca
🇺🇸Seneca, South Carolina, United States
Fairbanks Memorial Hospital
🇺🇸Fairbanks, Alaska, United States
Alaska Breast Care and Surgery LLC
🇺🇸Anchorage, Alaska, United States
Alaska Regional Hospital
🇺🇸Anchorage, Alaska, United States
Alaska Women's Cancer Care
🇺🇸Anchorage, Alaska, United States
Highlands Oncology Group-Rogers
🇺🇸Rogers, Arkansas, United States
Saint Patrick Hospital - Community Hospital
🇺🇸Missoula, Montana, United States
CHI Health Good Samaritan
🇺🇸Kearney, Nebraska, United States
Inspira Medical Center Vineland
🇺🇸Vineland, New Jersey, United States
Cancer Center of Western Wisconsin
🇺🇸New Richmond, Wisconsin, United States
Swedish Medical Center
🇺🇸Englewood, Colorado, United States
Greenwich Hospital
🇺🇸Greenwich, Connecticut, United States
Smilow Cancer Hospital Care Center at Saint Francis
🇺🇸Hartford, Connecticut, United States
Middlesex Hospital
🇺🇸Middletown, Connecticut, United States
Martin Medical Center
🇺🇸Stuart, Florida, United States
Robert and Carol Weissman Cancer Center at Martin Health
🇺🇸Stuart, Florida, United States
Martin Hospital South
🇺🇸Stuart, Florida, United States
Saint Alphonsus Cancer Care Center-Boise
🇺🇸Boise, Idaho, United States
Saint Luke's Mountain States Tumor Institute - Meridian
🇺🇸Meridian, Idaho, United States
Kootenai Cancer Center
🇺🇸Post Falls, Idaho, United States
Saint Luke's Mountain States Tumor Institute-Twin Falls
🇺🇸Twin Falls, Idaho, United States
Hematology/Oncology Clinic LLP
🇺🇸Baton Rouge, Louisiana, United States
Steward Saint Elizabeth's Medical Center
🇺🇸Brighton, Massachusetts, United States
Clackamas Radiation Oncology Center
🇺🇸Clackamas, Oregon, United States
Legacy Mount Hood Medical Center
🇺🇸Gresham, Oregon, United States
Providence Milwaukie Hospital
🇺🇸Milwaukie, Oregon, United States
Providence Willamette Falls Medical Center
🇺🇸Oregon City, Oregon, United States
Hurley Medical Center
🇺🇸Flint, Michigan, United States
Genesys Hurley Cancer Institute
🇺🇸Flint, Michigan, United States
Genesys Regional Medical Center
🇺🇸Grand Blanc, Michigan, United States
Allegiance Health
🇺🇸Jackson, Michigan, United States
Borgess Medical Center
🇺🇸Kalamazoo, Michigan, United States
Bronson Methodist Hospital
🇺🇸Kalamazoo, Michigan, United States
West Michigan Cancer Center
🇺🇸Kalamazoo, Michigan, United States
Saint Mary Mercy Hospital
🇺🇸Livonia, Michigan, United States
Mid-Michigan Medical Center - Midland
🇺🇸Midland, Michigan, United States
Saint John Macomb-Oakland Hospital
🇺🇸Warren, Michigan, United States
Greenville Health System Cancer Institute-Easley
🇺🇸Easley, South Carolina, United States
Lakeland Community Hospital
🇺🇸Niles, Michigan, United States
Saint Joseph Mercy Oakland
🇺🇸Pontiac, Michigan, United States
McLeod Regional Medical Center
🇺🇸Florence, South Carolina, United States
Saint Francis Hospital
🇺🇸Greenville, South Carolina, United States
Abbott-Northwestern Hospital
🇺🇸Minneapolis, Minnesota, United States
Hennepin County Medical Center
🇺🇸Minneapolis, Minnesota, United States
Tom K Lee Inc
🇺🇸Oakland, California, United States
Huntington Memorial Hospital
🇺🇸Pasadena, California, United States
Doctors Medical Center- JC Robinson Regional Cancer Center
🇺🇸San Pablo, California, United States
John Muir Medical Center-Walnut Creek
🇺🇸Walnut Creek, California, United States
Breastlink Medical Group Inc
🇺🇸Santa Ana, California, United States
Heartland Cancer Research NCORP
🇺🇸Decatur, Illinois, United States
Crossroads Cancer Center
🇺🇸Effingham, Illinois, United States
Illinois CancerCare-Eureka
🇺🇸Eureka, Illinois, United States
Northwestern Medicine Cancer Center Delnor
🇺🇸Geneva, Illinois, United States
Illinois CancerCare-Macomb
🇺🇸Macomb, Illinois, United States
Holy Family Medical Center
🇺🇸Monmouth, Illinois, United States
Illinois CancerCare-Monmouth
🇺🇸Monmouth, Illinois, United States
Mid-Illinois Hematology Oncology Associates Limited
🇺🇸Normal, Illinois, United States
Ottawa Regional Hospital and Healthcare Center
🇺🇸Ottawa, Illinois, United States
Illinois CancerCare-Pekin
🇺🇸Pekin, Illinois, United States
OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
🇺🇸Pekin, Illinois, United States
Illinois CancerCare-Peoria
🇺🇸Peoria, Illinois, United States
Illinois CancerCare-Princeton
🇺🇸Princeton, Illinois, United States
Memorial Medical Center
🇺🇸Springfield, Illinois, United States
Northwestern Medicine Cancer Center Warrenville
🇺🇸Warrenville, Illinois, United States
Elkhart Clinic
🇺🇸Elkhart, Indiana, United States
Elkhart General Hospital
🇺🇸Elkhart, Indiana, United States
IU Health La Porte Hospital
🇺🇸La Porte, Indiana, United States
Cancer Care Partners LLC
🇺🇸Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-Mishawaka
🇺🇸Mishawaka, Indiana, United States
Michiana Hematology Oncology PC-Plymouth
🇺🇸Plymouth, Indiana, United States
Northern Indiana Cancer Research Consortium
🇺🇸South Bend, Indiana, United States
Siouxland Regional Cancer Center
🇺🇸Sioux City, Iowa, United States
Michiana Hematology Oncology PC-Westville
🇺🇸Westville, Indiana, United States
Mercy Hospital-Joplin
🇺🇸Joplin, Missouri, United States
Centerpoint Medical Center LLC
🇺🇸Independence, Missouri, United States
Phelps County Regional Medical Center
🇺🇸Rolla, Missouri, United States
Saint John's Clinic-Rolla-Cancer and Hematology
🇺🇸Rolla, Missouri, United States
Heartland Regional Medical Center
🇺🇸Saint Joseph, Missouri, United States
Saint Luke's East - Lee's Summit
🇺🇸Lee's Summit, Missouri, United States
Mercy Hospital Springfield
🇺🇸Springfield, Missouri, United States
Novant Health Presbyterian Medical Center
🇺🇸Charlotte, North Carolina, United States
Randolph Hospital
🇺🇸Asheboro, North Carolina, United States
Lake Norman Hematology Oncology Specialists-Mooresville
🇺🇸Mooresville, North Carolina, United States
Riverside Methodist Hospital
🇺🇸Columbus, Ohio, United States
Columbus NCI Community Oncology Research Program
🇺🇸Columbus, Ohio, United States
Grant Medical Center
🇺🇸Columbus, Ohio, United States
Delaware Health Center-Grady Cancer Center
🇺🇸Delaware, Ohio, United States
Lancaster Radiation Oncology
🇺🇸Lancaster, Ohio, United States
Southern Ohio Medical Center
🇺🇸Portsmouth, Ohio, United States
Baylor University Medical Center
🇺🇸Dallas, Texas, United States
M D Anderson Cancer Center
🇺🇸Houston, Texas, United States
Virginia Mason CCOP
🇺🇸Seattle, Washington, United States
Rockwood Clinic
🇺🇸Spokane, Washington, United States
EvergreenHealth Medical Center
🇺🇸Kirkland, Washington, United States
PeaceHealth Southwest Medical Center
🇺🇸Vancouver, Washington, United States
Compass Oncology Vancouver
🇺🇸Vancouver, Washington, United States
Doctor's Hospital of Laredo
🇺🇸Laredo, Texas, United States
Northeast Alabama Regional Medical Center
🇺🇸Anniston, Alabama, United States
Providence Hospital
🇺🇸Mobile, Alabama, United States
East Bay Radiation Oncology Center
🇺🇸Castro Valley, California, United States
John Muir Medical Center-Concord Campus
🇺🇸Concord, California, United States
Valley Medical Oncology Consultants-Castro Valley
🇺🇸Castro Valley, California, United States
City of Hope Comprehensive Cancer Center
🇺🇸Duarte, California, United States
Epic Care-Dublin
🇺🇸Dublin, California, United States
Bay Area Breast Surgeons Inc
🇺🇸Emeryville, California, United States
Epic Care Partners in Cancer Care
🇺🇸Emeryville, California, United States
Huntsman Cancer Institute/University of Utah
🇺🇸Salt Lake City, Utah, United States
Valley Medical Oncology Consultants-Fremont
🇺🇸Fremont, California, United States
Los Angeles County-USC Medical Center
🇺🇸Los Angeles, California, United States
USC / Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
El Camino Hospital
🇺🇸Mountain View, California, United States
Highland General Hospital
🇺🇸Oakland, California, United States
Bay Area Tumor Institute
🇺🇸Oakland, California, United States
Front Range Cancer Specialists
🇺🇸Fort Collins, Colorado, United States
Mercy Medical Center
🇺🇸Durango, Colorado, United States
Penrose-Saint Francis Healthcare
🇺🇸Colorado Springs, Colorado, United States
Wilcox Memorial Hospital and Kauai Medical Clinic
🇺🇸Lihue, Hawaii, United States
Littleton Adventist Hospital
🇺🇸Littleton, Colorado, United States
McKee Medical Center
🇺🇸Loveland, Colorado, United States
Cancer Center of Kansas - Dodge City
🇺🇸Dodge City, Kansas, United States
Cancer Center of Kansas - El Dorado
🇺🇸El Dorado, Kansas, United States
Cancer Center of Kansas - McPherson
🇺🇸McPherson, Kansas, United States
Saint Luke's South Hospital
🇺🇸Overland Park, Kansas, United States
Boulder Community Hospital
🇺🇸Boulder, Colorado, United States
North Colorado Medical Center
🇺🇸Greeley, Colorado, United States
Rocky Mountain Cancer Centers-Sky Ridge
🇺🇸Lone Tree, Colorado, United States
Sky Ridge Medical Center
🇺🇸Lone Tree, Colorado, United States
Hutchinson Area Health Care
🇺🇸Hutchinson, Minnesota, United States
Castle Medical Center
🇺🇸Kailua, Hawaii, United States
Poudre Valley Hospital
🇺🇸Fort Collins, Colorado, United States
Rocky Mountain Cancer Centers-Parker
🇺🇸Parker, Colorado, United States
Cancer Center of Kansas - Chanute
🇺🇸Chanute, Kansas, United States
Cancer Center of Kansas-Kingman
🇺🇸Kingman, Kansas, United States
Cancer Center of Kansas - Parsons
🇺🇸Parsons, Kansas, United States
Pali Momi Medical Center
🇺🇸'Aiea, Hawaii, United States
Menorah Medical Center
🇺🇸Overland Park, Kansas, United States
Saint Anthony Hospital
🇺🇸Lakewood, Colorado, United States
Cancer Center of Kansas - Fort Scott
🇺🇸Fort Scott, Kansas, United States
Lawrence Memorial Hospital
🇺🇸Lawrence, Kansas, United States
Fairview-Southdale Hospital
🇺🇸Edina, Minnesota, United States
Minnesota Oncology Hematology PA-Maplewood
🇺🇸Maplewood, Minnesota, United States
Cancer Center of Kansas - Newton
🇺🇸Newton, Kansas, United States
Cancer Center of Kansas-Liberal
🇺🇸Liberal, Kansas, United States
Cancer Center of Kansas-Manhattan
🇺🇸Manhattan, Kansas, United States
Unity Hospital
🇺🇸Fridley, Minnesota, United States
Kansas City NCI Community Oncology Research Program
🇺🇸Prairie Village, Kansas, United States
Metro Minnesota Community Oncology Research Consortium
🇺🇸Saint Louis Park, Minnesota, United States
Saint John's Hospital - Healtheast
🇺🇸Maplewood, Minnesota, United States
Regions Hospital
🇺🇸Saint Paul, Minnesota, United States
Lakeview Hospital
🇺🇸Stillwater, Minnesota, United States
Rice Memorial Hospital
🇺🇸Willmar, Minnesota, United States
New Ulm Medical Center
🇺🇸New Ulm, Minnesota, United States
Park Nicollet Clinic - Saint Louis Park
🇺🇸Saint Louis Park, Minnesota, United States
Wayne State University/Karmanos Cancer Institute
🇺🇸Detroit, Michigan, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
Saint John Hospital and Medical Center
🇺🇸Detroit, Michigan, United States
University of Oklahoma Health Sciences Center
🇺🇸Oklahoma City, Oklahoma, United States
Legacy Good Samaritan Hospital and Medical Center
🇺🇸Portland, Oregon, United States
Providence Portland Medical Center
🇺🇸Portland, Oregon, United States
Western Oncology Research Consortium
🇺🇸Portland, Oregon, United States
Providence Saint Vincent Medical Center
🇺🇸Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center
🇺🇸Portland, Oregon, United States
Porter Adventist Hospital
🇺🇸Denver, Colorado, United States
Colorado Blood Cancer Institute
🇺🇸Denver, Colorado, United States
Presbyterian - Saint Lukes Medical Center - Health One
🇺🇸Denver, Colorado, United States
Rocky Mountain Cancer Centers-Midtown
🇺🇸Denver, Colorado, United States
SCL Health Saint Joseph Hospital
🇺🇸Denver, Colorado, United States
Rocky Mountain Cancer Centers-Rose
🇺🇸Denver, Colorado, United States
Rose Medical Center
🇺🇸Denver, Colorado, United States
Colorado Cancer Research Program NCORP
🇺🇸Denver, Colorado, United States
Missouri Valley Cancer Consortium
🇺🇸Omaha, Nebraska, United States
Alegent Health Immanuel Medical Center
🇺🇸Omaha, Nebraska, United States
Alegent Health Bergan Mercy Medical Center
🇺🇸Omaha, Nebraska, United States
Alegent Health Lakeside Hospital
🇺🇸Omaha, Nebraska, United States
Creighton University Medical Center
🇺🇸Omaha, Nebraska, United States
The Medical Center of Aurora
🇺🇸Aurora, Colorado, United States
Saint Joseph Mercy Hospital
🇺🇸Ann Arbor, Michigan, United States
Michigan Cancer Research Consortium NCORP
🇺🇸Ann Arbor, Michigan, United States
Rocky Mountain Cancer Centers-Boulder
🇺🇸Boulder, Colorado, United States
Florida Hospital Orlando
🇺🇸Orlando, Florida, United States
Southeast Clinical Oncology Research (SCOR) Consortium NCORP
🇺🇸Winston-Salem, North Carolina, United States
Anchorage Oncology Centre
🇺🇸Anchorage, Alaska, United States
Katmai Oncology Group
🇺🇸Anchorage, Alaska, United States
Rocky Mountain Cancer Centers-Penrose
🇺🇸Colorado Springs, Colorado, United States
University of Hawaii Cancer Center
🇺🇸Honolulu, Hawaii, United States
Kuakini Medical Center
🇺🇸Honolulu, Hawaii, United States
Kapiolani Medical Center for Women and Children
🇺🇸Honolulu, Hawaii, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Ochsner Medical Center Jefferson
🇺🇸New Orleans, Louisiana, United States
Saint Luke's Hospital of Kansas City
🇺🇸Kansas City, Missouri, United States
North Kansas City Hospital
🇺🇸Kansas City, Missouri, United States
Heartland Hematology and Oncology Associates Incorporated
🇺🇸Kansas City, Missouri, United States
Research Medical Center
🇺🇸Kansas City, Missouri, United States
Associates In Womens Health
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas-Wichita Medical Arts Tower
🇺🇸Wichita, Kansas, United States
Cancer Center of Kansas - Wichita
🇺🇸Wichita, Kansas, United States
Via Christi Regional Medical Center
🇺🇸Wichita, Kansas, United States
Wichita NCI Community Oncology Research Program
🇺🇸Wichita, Kansas, United States
Presbyterian Kaseman Hospital
🇺🇸Albuquerque, New Mexico, United States
Highland Hospital
🇺🇸Rochester, New York, United States
University of Rochester
🇺🇸Rochester, New York, United States
The University of Arizona Medical Center-University Campus
🇺🇸Tucson, Arizona, United States
Greenville Health System Cancer Institute-Butternut
🇺🇸Greenville, South Carolina, United States
Greenville Health System Cancer Institute-Faris
🇺🇸Greenville, South Carolina, United States
Methodist Medical Center of Illinois
🇺🇸Peoria, Illinois, United States
Saint Vincent Healthcare
🇺🇸Billings, Montana, United States
Welch Cancer Center
🇺🇸Sheridan, Wyoming, United States
Cancer Center of Kansas - Winfield
🇺🇸Winfield, Kansas, United States
Legacy Salmon Creek Hospital
🇺🇸Vancouver, Washington, United States
Park Ridge Hospital Breast Health Center
🇺🇸Hendersonville, North Carolina, United States
Cancer Center of Kansas - Pratt
🇺🇸Pratt, Kansas, United States
Cancer Center of Kansas - Wellington
🇺🇸Wellington, Kansas, United States
Saint Francis Regional Medical Center
🇺🇸Shakopee, Minnesota, United States
Strecker Cancer Center-Belpre
🇺🇸Belpre, Ohio, United States
Carolina Blood and Cancer Care Associates PA
🇺🇸Rock Hill, South Carolina, United States