Can screening programmes for abdominal aortic aneurysm safely be made more efficient by targeting them at people at the highest risk of disease?

Not Applicable

• Conditions: Abdominal aortic aneurysm; Circulatory System

• Registration Number: ISRCTN49655213
• Lead Sponsor: niversity of Leicester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-04-20
• Last Update Posted: 2 May 2022
• Study Completion: 2025-10-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: Male
• Target Recruitment: 460000

Inclusion Criteria

Men invited for AAA screening by the NHS AAA Screening Programme (2013 to date)

Exclusion Criteria

Men who have opted out of NHS data sharing or NHS AAA Screening Programme research.

Study & Design

• Study Type: Other
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Diagnostic accuracy of AAA screening – sensitivity of targeted screening for AAA detection in comparison to whole population screening. AAA detection will be determined from AAA screening records at a single time point

Secondary Outcome Measures

Name	Time	Method
<br> 1. Effectiveness of targeted screening – using the baseline of whole population screening the clinical and economic effectiveness of targeted screening will be estimated using a validated discrete event simulation model. Model parameters will be determined from the analysis of AAA screening outcome data at a single time point<br> 2. Diagnostic accuracy will be determined from data provided by the NHS AAA Screening Programme. This consists of attendance for screening and binary screening outcome (attendance yes/no, aneurysm yes/no). The gold standard for diagnostic accuracy will be the observed results from whole population screening. The results of targeted screening will be compared to this with data for AAA screening outcomes for each individual compared across the two strategies at a single time point<br>