Feasibility of using the Pap-smear as a screening device for the detection of endometrial and ovarian cancer
Completed
- Conditions
- Cervical smear (Pap-smear)uterine cancer (endometrial cancer)10038594
- Registration Number
- NL-OMON39020
- Lead Sponsor
- niversitair Medisch Centrum Sint Radboud
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
Endometrial cancer: patient suspected of having endometrial cancer i.e. postmenopausal bleeding
Ovarian cancer: patient highly (99% certainty) suspected of having ovarian cancer. This will be based on RMI>200, CA125/CEA ratio, ascites, peritoneal depositions, omental cake or even laparoscopic evaluation.
Exclusion Criteria
Previous pelvic radiotherapy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main study parameter is the correlation between mutations found in the<br /><br>Pap-smear and the pipelle endometrial sampling and the primary tumor.</p><br>
- Secondary Outcome Measures
Name Time Method <p>The main study parameter is the correlation between mutations found in the<br /><br>vaginal swab and the pipelle endometrial sampling and the primary tumor.<br /><br>To assess the correlation between the results of the mutation analysis and<br /><br>tumour characteristics (histology, stage).</p><br>