Transversus Abdominis Plane Block Plus Quadratus Lumborum Block or Retrolaminar Block of Multiple Injections for Postoperative Analgesia Following Laparoscopic Colorectal Surgery

Phase 4

• Conditions: Quadratus Lumborum Block; Analgesia; Laparoscopic; Colorectal
• Interventions: Procedure: Retrolaminar block on the operative side; Procedure: Quadratus lumborum block on the operative side; Procedure: Transversus abdominis plane block on the nonoperative side

• Registration Number: NCT05416866
• Lead Sponsor: dong zhang

Brief Summary

Our hypothesis was that transversus abdominis plane block plus retrolaminar block would reduce postoperative sufentanil consumption and provide superior analgesia compared with transversus abdominis plane block plus quadratus lumborum block for laparoscopic colorectal surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-05-26
• Status Verified: 2022-06
• Study First Submitted QC: 2022-06-08
• Last Update Submitted: 2022-06-08
• Study First Posted: 2022-06-14
• Last Update Posted: 2022-06-14
• Study Start: 2022-06-20
• Primary Completion: 2022-11-20
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• American Society of Anesthesiologists (ASA) physical status I-II class
• Colorectal cancer patients
• 18 and 80 years old
• Elective laparoscopic colorectal surgery

Exclusion Criteria

• serious complications associated with other systems:
• severe cardiac insufficiency
• renal failure
• hepatic encephalopathy
• infection in the block injection area
• coagulopathy
• a known allergy to local anesthetics
• a previous history of tranquilizer or opioid abuse,
• body mass index (BMI) greater than 30 kg/m2 or less than 18 kg/m2,
• inability to cooperate with the assessment of visual analogue scale (VAS) pain scores
• refusal to participate in the study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
TR group	Retrolaminar block on the operative side	ultrasound-guided transversus abdominis plane block with 20 ml mixture 0.20% ropivacaine + dexamethasone 5 mg and retrolaminar block with 30-40 ml mixture 0.20% ropivacaine + dexamethasone 5 mg
TQ group	Transversus abdominis plane block on the nonoperative side	ultrasound-guided transversus abdominis plane block with 20 ml mixture 0.20% ropivacaine + dexamethasone 5 mg and quadratus lumborum block with 30 ml mixture 0.20% ropivacaine + dexamethasone 5 mg
TR group	Transversus abdominis plane block on the nonoperative side	ultrasound-guided transversus abdominis plane block with 20 ml mixture 0.20% ropivacaine + dexamethasone 5 mg and retrolaminar block with 30-40 ml mixture 0.20% ropivacaine + dexamethasone 5 mg
TQ group	Quadratus lumborum block on the operative side	ultrasound-guided transversus abdominis plane block with 20 ml mixture 0.20% ropivacaine + dexamethasone 5 mg and quadratus lumborum block with 30 ml mixture 0.20% ropivacaine + dexamethasone 5 mg

Primary Outcome Measures

Name	Time	Method
the cumulative consumption of sufentanil	24 hours after nerves block	the outcome in micrograms

Secondary Outcome Measures

Name	Time	Method
the patient's mean arterial pressure (MAP), HR at rest and during movement at 1, 2, 4, 6, 8, 12, 18, 24 after nerves block	the time for completion of nerves block was time 0	MAP in mmHg, HR in rate/one minute.
cumulative sufentanil consumption at predetermined time intervals	within 24 hour after nerves block	the outcome in minutes
time until the earliest single patient-controlled analgesia (PCA) dose of sufentanil	within 24 hour after nerves block	the outcome in minutes
the total dose of rescue analgesia and antiemetic	within 24 hour after nerves block	the outcome in milligrams
the number of PCA press	within 24 hour after nerves block	the outcome in frequency
time until the earliest rescue analgesia and antiemetic	within 24 hour after nerves block	the outcome in minutes
block-related complications	within 24 hour after nerves block	such as hematoma, infection, quadriceps weakness, pneumothorax, deep visceral injury, and evidence of systemic toxicity to the local anesthetic
other side events	within 24 hour after nerves block	such as bradycardia (HR less than 60 beats per min), hypotension (systolic blood pressure less than 90 mmHg or more than 20% lower than baseline), hypoxemia (SpO2 less than 90%), respiratory depression (RR less than 10 breaths per min lasting for more than 10 min), pruritus, backache, nausea and vomiting
patient satisfaction with pain management	at 24th hour after nerves block	Patient satisfaction on postoperative analgesia using a 5-point scale (1 = very unsatisfied, 2 = unsatisfied, 3 = fair, 4 = satisfied, and 5 = very satisfied)
the length of hospital stay	up to 2 weeks	the outcome in days
Visual Analog Score (VAS) for pain at rest and during movement at 1, 2, 4, 6, 8, 12, 18, 24 after nerves block	the time for completion of nerves block was time 0	The VAS is an internationally recognized scale for assessment of pain on an 11-point scale ranging from 0 to 10 points, with 0 defined as no pain and 10 defined as the worst pain imaginable (units on a scale)