se of preoperative desmopressin in preventing bleeding in patients treated with selective serotonin reuptake inhibitors (SSRIs)

Completed

• Conditions: Primary haemostasis disorder; Surgery; Procedural bleeding

• Registration Number: ISRCTN10353850
• Lead Sponsor: Hospital Gelderse Vallei (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12-20
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 300

Inclusion Criteria

1. Patients aged over 18 who receive a serotonergic antidepressant (fluvoxamine, fluoxetine, paroxetine, sertraline, venlafaxine, clomipramine, citalopram) at least started two weeks before the surgery
2. Surgery: orthopedic, abdominal, breast

Exclusion Criteria

1. No informed consent
2. Disorder in primary haemostasis
3. Hyponatraemia (sodium [serum] less than 130 mmol/l)
4. Laparoscopic surgery
5. Use of vitamin K antagonists, aspirin, iron supplements, methotrexate, heparin
6. Acute coronary syndrome (unstable angina and myocardial infarction)
7. Spinal anaesthesia during surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pre- and post-operative blood loss.

Secondary Outcome Measures

Name	Time	Method
1. Peri- and post-operative haemoglobin<br>2. Number of peri-operative blood transfusion<br>3. Peri-operative fluid infusion<br>4. Post-operative drainage