The Effect of Duloxetine on Bone Metabolism
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 102
- 试验地点
- 1
- 主要终点
- DXA
研究概览
简要总结
The aim of the study was to determine the effect of duloxetine as monotherapy on biochemical markers and bone mineral density.
详细描述
51 patients diagnosed with chronic pain or fibromyalgia syndrome who were using duloxetine for at least 3 months and age and sex matched 51 healthy individuals were recruited for this cross-sectional study. Bone mineral density of both groups were measured by dual energy x ray absorbsiometry(DXA), bone biochemical markers, serum calcium, and vitamin D levels were investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •>18 years or <50 years
- •patients using duloxetine for at least 3 months due to chronic pain or fibromyalgia
排除标准
- •postmenopausal women
- •clinical conditions which cause secondary osteoporosis
- •patients using medication that cause secondary osteoporosis
- •pregnancy and malignity
研究组 & 干预措施
Duloxetine Group
Patients who use duloxetine at least 3 months for chronic pain or fibromyalgia
干预措施: Duloxetine (Drug)
结局指标
主要结局
DXA
时间窗: 3 months
Bone mineral densitomtry
CTX
时间窗: 3 months
C-terminal telopeptide
OC
时间窗: 3 months
Osteocalcin
25-OH VITD3
时间窗: 3 months
25-hydroxyvitamin D3
次要结局
未报告次要终点
研究者
Bayram Kelle
Associate Professor
Cukurova University