Investigating the Functional Characteristics During Wakefulness and Sleep Based on SEEG
- Conditions
- SleepRefractory Epilepsy
- Interventions
- Procedure: SEEG recording and CCEP
- Registration Number
- NCT06524479
- Lead Sponsor
- Xuanwu Hospital, Beijing
- Brief Summary
This study aims to collect electrophysiological and clinical data from patients aged 14-65 with drug-resistant epilepsy who underwent SEEG. The collected data will be analyzed to investigate the functional connectivity during wakefulness and sleep states.
- Detailed Description
Sleep serves as a fundamental physiological state whose disruption has profound implications for neurological health. The daily alternation between sleep and wakefulness reflects an intrinsic circadian rhythm that orchestrates critical fluctuations in cortical excitability and functional connectivity throughout the brain. The cerebral cortex, comprising approximately 80% of total brain volume, forms the neural substrate for higher-order cognitive functions including sensory perception, executive control, and memory processes. Importantly, sleep acts as a global brain modulator that dynamically reorganizes patterns of neural communication across distributed cortical and subcortical networks.
Stereoelectroencephalography (SEEG) provides direct access to intracranial electrophysiological activity with exceptional spatiotemporal resolution. When combined with single-pulse electrical stimulation (SPES), this powerful methodology enables quantitative assessment of inter-regional connectivity through analysis of evoked potentials, allowing precise characterization of both connection strength and directionality. This integrated approach offers unique opportunities to examine how different vigilance states modulate cortical excitability and reorganize functional brain networks, particularly in clinical populations with neurological disorders. The ability to track state-dependent changes in network dynamics provides crucial insights into both normal brain function and pathological conditions.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 20
- Drug-resistant focal epilepsy
- Justified SEEG exploration in the context of presurgical assessment of epilepsy
- Subjects will be a part of the epilepsy-monitoring unit for long-term SEEG recordings and analysis
- Written non-opposition to study participation
- Pregnant women (Contraindication to SEEG exploration)
- Subjects that experience surgical complications during the implant procedure will be excluded from the study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description SEEG recording and CCEP SEEG recording and CCEP SEEG recordings using cortico-cortical evoked potentials (CCEPs) are conducted both during daytime and sleep to assess functional connectivity and network dynamics within the brain. The process involves delivering electrical stimuli to specific cortical areas and recording the evoked responses in distant cortical regions. This method helps in understanding the brain's connectivity patterns, distinguishing between normal and pathological conditions, and identifying critical areas for surgical planning in epilepsy patients. The variations between daytime and sleep recordings can provide insights into how brain connectivity changes across different states.
- Primary Outcome Measures
Name Time Method SEEG recordings with SPES during daytime and sleeptime 48 hours Single-pulse electrical stimulation (SPES) serves as an effective dynamic marker for mapping functional brain connectivity. The stimulation parameters were set at 0.05 Hz, single biphasic pulses, 90 μs per phase, 4 mA.
- Secondary Outcome Measures
Name Time Method Dynamic melatonin levels 48 hours Collection of melatonin during the day (12 times a day: at 9:00 am, 10:00 am, 11:00 am, 2:00pm, 3:00pm, 4:00pm, 5:00pm, 7:00pm, 8:00pm, 9:00pm, 10:00pm , 11:00pm and 12:00pm) with salivette measurement. Salivary melatonin was measured by radioimmunoassay.
Dynamic cortisone levels 48 hours Collection of salivary cortisone during the day (12 times a day: at 9:00 am, 10:00 am, 11:00 am, 2:00pm, 3:00pm, 4:00pm, 5:00pm, 7:00pm, 8:00pm, 9:00pm, 10:00pm , 11:00pm and 12:00pm) with salivette measurement.
Other sleep-related biomarkers levels 48 hours Collection of salivary during the day (12 times a day: at 9:00 am, 10:00 am, 11:00 am, 2:00pm, 3:00pm, 4:00pm, 5:00pm, 7:00pm, 8:00pm, 9:00pm, 10:00pm , 11:00pm and 12:00pm) with salivette measurement.
Trial Locations
- Locations (1)
Xuanwu Hospital, Beijing
🇨🇳Beijing, Beijing, China