Acute Effects of Endurance Exercise on Breastmilk Composition

Not Applicable

Completed

• Conditions: Breastmilk

• Registration Number: NCT05042414
• Lead Sponsor: Norwegian University of Science and Technology

Brief Summary

The investigators will determine the acute effect of exercise on breastmilk composition. Participants will come in to the lab on three different days, out of which they will exercise on two of these days and rest in the lab on the third day. The conditions will be randomly allocated to each participant. Breastmilk samples will be obtained in the morning of each test day, as well as immediately after, one hour after and four hours after the exercise/rest condition. Dietary intake will be standardized on the test days. At the time of study commencement, the trial (including planned analyses) is not fully funded. Additional milk will be stored for future analyses (not yet specified) when funding is secured.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-08-13
• Study Start: 2021-08-24
• Study First Submitted QC: 2021-09-04
• Study First Posted: 2021-09-13
• Primary Completion: 2022-06-01
• Study Completion: 2022-06-01
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-07
• Last Update Posted: 2022-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 20

Inclusion Criteria

• 6 to 12 weeks postpartum
• Exclusive breastfeeding
• Term birth

Exclusion Criteria

• Known cardiovascular disease
• Type 1 or 2 diabetes mellitus
• Limited ability to exercise

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Primary Outcome Measures

Name	Time	Method
Breastmilk metabolite composition	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Metabolomics profiling

Secondary Outcome Measures

Name	Time	Method
Leptin	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Concentration in breastmilk
Cytokine profiling (Multiplex 27)	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Concentration in breastmilk
Insulin	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Concentration in breastmilk
Insulin Growth Factor-1	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Concentration in breastmilk
Adiponectin	Change from before exercise to after exercise (+0 hour, +1 hour, and + 4 hours)	Concentration in breastmilk

Trial Locations

Locations (1)

Department of Circulation and Medical Imaging, NTNU; 🇳🇴 Trondheim, Norway