Perioperative Analgesia for Knee Arthroplasty

Not Applicable

Completed

• Conditions: Topic: Musculoskeletal; Subtopic: Musculoskeletal (all Subtopics); Disease: Musculoskeletal; Musculoskeletal Diseases

• Registration Number: ISRCTN60611146
• Lead Sponsor: niversity Hospitals Coventry & Warwickshire NHS Trust (UK)

Brief Summary

2015 protocol in: https://www.ncbi.nlm.nih.gov/pubmed/26692559 2017 results in: https://www.ncbi.nlm.nih.gov/pubmed/28663395

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-11-08
• Study Completion: 2015-10-31
• Last Update Posted: 9 September 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 264

Inclusion Criteria

All patients undergoing an elective primary unilateral total knee arthroplasty under the care of an orthopaedic consultant at University Hospitals Coventry and Warwickshire NHS Trust.
Target Gender: Male & Female ; Lower Age Limit 18 years

Exclusion Criteria

1. A concomitant medical or psychiatric problem which, in the opinion of the Investigator, would prevent completion of treatment or follow-up
2. Patients with a preoperative history of neurological abnormality in the ipsilateral leg
3. Patients with specific contraindication to the analgesic agents used
4. Participation in a clinical trial of an investigational medicinal product in the last 90 days
5. Previous entry in the present trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale; Timepoint(s): Pre-physiotherapy on the first post-operative day

Secondary Outcome Measures

Name	Time	Method
<br> 1. As required analgesia; timepoint(s): the total use of as required analgesia in the first 48 hours after the operation<br> 2. Bed transfers; timepoint(s): day 1 and 2 postoperatively<br> 3. Distance mobilised; timepoint(s): day 1 and 2 postoperatively<br> 4. EQ-5D-5L; timepoint(s): baseline and 6 weeks postoperatively<br> 5. Knee range of movement; timepoint(s): day 1 and 2 postoperatively<br> 6. Ordinal Pain Score; timepoint(s): routinely collected by nursing staff every 6 hours for the first 48 hours following surgery<br> 7. Oxford Knee Score; timepoint(s): baseline and 6 weeks postoperatively<br> 8. Routine physio assessments<br> 9. Bed transfers and distance mobilised<br> 9. Straight leg raise; timepoint(s): day 1 and 2 postoperatively<br> 10. Timed up and go; timepoint(s): day 1 and 2 postoperatively<br>