ow Dose Dexmedetomidine as an alternative to narcotic pain-killers in daycare surgeries.
Phase 3
- Conditions
- Health Condition 1: C679- Malignant neoplasm of bladder, unspecified
- Registration Number
- CTRI/2019/02/017655
- Lead Sponsor
- Post Graduate Institute of Medical Education and research
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.American Society of Anesthesiologists physical status I or II
2.Age of 18â??65 years
3.Either gender
4.Estimated operation time of <= 2 hours and anaesthesia time of <= 3 hours
5.Written informed consent to undergo the therapeutic regimen
Exclusion Criteria
1.Renal dysfunction (serum creatinine > 1.2mg/dl)
2.Liver dysfunction (liver enzymes twice the normal range or higher)
3.History of chronic use of sedatives/ narcotics or analgesics
4.BMI more than 30 kg/m2 or less than 15 kg/m2
5.Allergy to study medication
6.Participants devoid of postoperative telephone access
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to emergenceTimepoint: Time to emergence
- Secondary Outcome Measures
Name Time Method Secondary objectives: <br/ ><br>1.Predicted EC50 of propofol for induction <br/ ><br>2.Total propofol requirment for induction <br/ ><br>3. Intraoperative anaesthetic agent (MAC) requirement, <br/ ><br>4. Postoperative pain scores (VNRS) <br/ ><br>5. Perioperative analgesia requirements <br/ ><br>6. PONV <br/ ><br>7. Drowsiness (RASS score), <br/ ><br>8. Duration of PACU stay, <br/ ><br>9. Any adverse events. <br/ ><br>Timepoint: 120 minutes post intervention